与2,6-双（1h -咪唑-2-基）-4-甲氧基吡啶配合物的自旋交叉

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2025-01-14 DOI:10.1007/s11172-024-4446-9

O. G. Shakirova, I. A. Os’kina, E. V. Korotaev, S. A. Petrov, S. G. Kozlova, L. S. Klyushova, A. Ya. Tikhonov, L. G. Lavrenova

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引用次数: 0

摘要

合成并研究了与2,6-二（1h -咪唑-2-基）-4-甲氧基吡啶(L)配合物[FeL2]Cl2•2H2O（1•2H2O）、[FeL2](NO3)2•H2O（2•H2O）、[FeL2](ClO4)2•0.5H2O（3•0.5H2O）和[FeL2]I2•c3h60（4•c3h60）。化合物的结构是基于漫反射、红外和Mössbauer光谱数据以及静态磁化率测量和量子化学计算的结果。除1•2H2O和1外，所合成化合物的有效磁矩的温度依赖性表现为自旋交叉伴随热致变色（颜色从橙色变为红紫色）。细胞毒和细胞抑制活性研究表明，该化合物对人肝癌HepG2细胞具有抑制作用，50%抑制浓度（IC50）为44.7±0.4 ~ 58.8±0.6µmol L−1。

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Spin crossover in new iron(ii) complexes with 2,6-bis(1H-imidazol-2-yl)-4-methoxypyridine

New iron(ii) complexes with 2,6-bis(1H-imidazol-2-yl)-4-methoxypyridine (L), viz., [FeL₂]Cl₂•2H₂O (1•2H₂O), [FeL₂](NO₃)₂•H₂O (2•H₂O), [FeL₂](ClO₄)₂•0.5H₂O (3•0.5H₂O), and [FeL₂]I₂•C₃H₆O (4•C₃H₆O) were synthesized and studied. Conclusions about the structure of the compounds are based on the diffuse reflectance, IR, and Mössbauer spectroscopy data and on the results of static magnetic susceptibility measurements and quantum chemical calculations. The temperature dependences of the effective magnetic moments of the compounds synthesized, except 1•2H₂O and 1, demonstrated features associated with spin crossover accompanied by thermochromism (changes of the color from orange to red-violet). The cytotoxic and cytostatic activity studies of the compounds in question revealed a cytostatic effect on the human hepatocellular carcinoma HepG2 cells characterized by 50% inhibitory concentration (IC₅₀) values from 44.7 ± 0.4 to 58.8 ± 0.6 µmol L⁻¹.

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.