解码大脑结构以确定唐氏综合症患者阿尔茨海默病的病理分期

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-01-14 DOI:10.1002/alz.14519

James T. Kennedy, Julie K. Wisch, Aylin Dincer, June Roman, Brian A. Gordon, Benjamin Handen, Tammie L. S. Benzinger, Elizabeth Head, Mark Mapstone, Bradley T. Christian, Dana L. Tudorascu, Charles L. Laymon, Sigan L. Hartley, Patrick Lao, Adam M. Brickman, Shahid H. Zaman, Beau M. Ances

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引用次数: 0

摘要

唐氏综合症（DS）中的阿尔茨海默病（AD）与大脑结构的变化有关。目前尚不清楚厚度和体积的变化是否可以识别阿尔茨海默病的分期，以及它们是否与其他遗传形式的阿尔茨海默病相似。

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Decoding brain structure to stage Alzheimer's disease pathology in Down syndrome

Alzheimer's disease (AD) in Down syndrome (DS) is associated with changes in brain structure. It is unknown if thickness and volumetric changes can identify AD stages and if they are similar to other genetic forms of AD.

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.