抑制脑血管内皮中IFITM3可减轻阿尔茨海默病相关表型

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-01-14 DOI:10.1002/alz.14543

Yijia Feng, Shengya Wang, Danlu Yang, Wu Zheng, Huwei Xia, Qinxin Zhu, Zhipeng Wang, Bolang Hu, Xinyi Jiang, Xuemei Qin, Chenkang Ni, Wenhao Pan, Yifan Zhao, Sipei Pan, Yun Zhang, Weihong Song

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引用次数: 0

摘要

干扰素诱导的跨膜蛋白3 （IFITM3）在阿尔茨海默病（AD）中调节γ-分泌酶。尽管IFITM3敲除可减少β淀粉样蛋白（Aβ）的产生，但其对AD的细胞特异性作用尚不清楚。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Inhibition of IFITM3 in cerebrovascular endothelium alleviates Alzheimer's-related phenotypes

Interferon-induced transmembrane protein 3 (IFITM3) modulates γ-secretase in Alzheimer's Disease (AD). Although IFITM3 knockout reduces amyloid β protein (Aβ) production, its cell-specific effect on AD remains unclear.

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.