巨噬细胞的再刺激会耗尽 T 细胞

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2025-01-14 DOI:10.1016/j.immuni.2024.12.010

Fernando Fernández-García, Barbara B. Maier

引用次数: 0

摘要

抑制 T 细胞衰竭是一种极具吸引力的癌症免疫疗法策略。在本期《免疫》杂志上，Waibl Polania 等人研究了调控终末 T 细胞衰竭的微环境信号，发现在胶质母细胞瘤中，是肿瘤相关巨噬细胞而非肿瘤细胞的抗原呈递驱动了终末 T 细胞衰竭。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Restimulation by macrophages exhausts T cells

Inhibiting T cell exhaustion is an attractive cancer immunotherapy strategy. In this issue of Immunity, Waibl Polania et al. examine the microenvironmental signals regulating terminal T cell exhaustion and find that antigen presentation by tumor-associated macrophages, not tumor cells, drives terminal T cell exhaustion in glioblastoma.

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.