伊朗南部器官移植受者内脏利什曼病的血清调查。

IF 0.8 4区医学 Q4 IMMUNOLOGY

Transplantation proceedings Pub Date : 2025-01-10 DOI:10.1016/j.transproceed.2024.12.030

Amirhossein Haydarian , Leila Morrabi , Mojtaba Shafiekhani , Mostafa Omidian , Bahador Sarkari

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引用次数: 0

摘要

背景：内脏利什曼病（VL）可在移植受者中变得活跃并引起特定问题。目前的研究是在伊朗南部法尔斯省的一个综合移植中心进行的，目的是对移植患者的VL进行血清学评估。方法：研究人群包括150例器官移植受者。对每位患者进行血样采集，并采用ELISA法检测血清抗利什曼原虫抗体。在对患者进行抽样时，将需要的信息记录在问卷中，最后用SPSS软件进行分析。结果：在150例招募的患者中，96例（64%）为男性，54例（36%）为女性。年龄最小18岁，最大85岁，平均年龄46.24（±15.13）岁。其中肾移植79例（52.66%），肝移植69例（46%），肠移植1例（0.66%），肾胰移植1例（0.66%）。参与者来自伊朗各省，其中大多数（61.33%）居住在法尔斯省。研究人群血清中检测到抗利什曼原虫抗体4例（2.7%）。VL的总血清阳性率与性别、年龄、移植类型、移植排斥反应、居住地等变量无统计学意义（P < 0.05）。结论：目前的研究结果表明，VL在伊朗南部的移植患者中有明显的血清阳性率。考虑到移植患者VL再活化的潜在风险，对其预防、及时诊断和治疗的需要更加明显。

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Serosurvey of Visceral Leishmaniasis in Organ Transplant Recipients in the South of Iran

Background

Visceral leishmaniasis (VL) can become active and cause specific problems in transplant recipients. The current study was conducted with the aim of serological evaluation of VL in transplant patients in a comprehensive transplantation center in Fars province southern Iran.

Methods

The study population included 150 organ transplant recipients. Blood sample was taken from each patient and the sera were evaluated for anti-Leishmania antibodies by an ELISA method. While sampling from patients, the required information was recorded in a questionnaire and finally analyzed by SPSS software.

Results

Out of the 150 recruited patients, 96 (64%) were men and 54 (36%) were women. The youngest participant was 18 years old and the oldest was 85, with an average age of 46.24 (±15.13). Among the participants, 79 (52.66%) had undergone kidney transplantation, 69 (46%) liver transplantation, 1 (0.66%) intestinal transplantation, and 1 (0.66%) had undergone SPK (kidney and pancreas) transplantation. The participants were from various provinces of Iran, with the majority (61.33%) residing in Fars province. Anti-Leishmania antibodies were detected in the sera of 4 individuals (2.7%) among the study population. The overall seroprevalence of VL did not have a statistically significant association with variables such as gender, age, type of transplant, transplant rejection, or place of residence (P > 0.05).

Conclusion

The results of the current study indicate a noticeable seroprevalence of VL in transplant patients in southern Iran. Given the potential risk of reactivation of VL in transplant patients, the need for greater attention to its prevention, timely diagnosis, and treatment becomes more obvious.

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来源期刊

Transplantation proceedings 医学-免疫学

CiteScore

1.70

自引率

0.00%

发文量

502

审稿时长

60 days

期刊介绍： Transplantation Proceedings publishes several different categories of manuscripts, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication. The first type of manuscripts consists of sets of papers providing an in-depth expression of the current state of the art in various rapidly developing components of world transplantation biology and medicine. These manuscripts emanate from congresses of the affiliated transplantation societies, from Symposia sponsored by the Societies, as well as special Conferences and Workshops covering related topics. Transplantation Proceedings also publishes several special sections including publication of Clinical Transplantation Proceedings, being rapid original contributions of preclinical and clinical experiences. These manuscripts undergo review by members of the Editorial Board. Original basic or clinical science articles, clinical trials and case studies can be submitted to the journal?s open access companion title Transplantation Reports.