靶向调节性T细胞脂质代谢增强肿瘤免疫治疗。

IF 9.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2025-01-10 DOI:10.1016/j.bbcan.2025.189259

Liu Yang , Xingyue Wang , Shurong Wang , Jing Shen , Yaling Li , Shengli Wan , Zhangang Xiao , Zhigui Wu

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引用次数: 0

摘要

作为免疫抑制细胞，调节性T细胞（Tregs）通过有效抑制其他免疫细胞的活性，对肿瘤微环境（TME）内的肿瘤免疫逃逸产生影响，从而极大地阻碍了抗肿瘤免疫应答。近年来，Tregs 的代谢特征已成为研究重点，尤其是脂质代谢在维持 Tregs 功能方面的重要作用。因此，旨在调节 Tregs 脂质代谢的靶向干预已被认为是提高肿瘤免疫疗法有效性的一种创新且前景广阔的方法。本综述全面概述了脂质代谢在调节 Tregs 功能中的关键作用，并特别关注以 Tregs 脂质代谢为靶点作为增强抗肿瘤免疫反应的创新方法。此外，我们还讨论了与这一策略相关的潜在机遇和挑战，旨在为提高癌症免疫疗法的疗效提供新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Targeting lipid metabolism in regulatory T cells for enhancing cancer immunotherapy

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Targeting lipid metabolism in regulatory T cells for enhancing cancer immunotherapy

As immunosuppressive cells, Regulatory T cells (Tregs) exert their influence on tumor immune escape within the tumor microenvironment (TME) by effectively suppressing the activity of other immune cells, thereby significantly impeding the anti-tumor immune response. In recent years, the metabolic characteristics of Tregs have become a focus of research, especially the important role of lipid metabolism in maintaining the function of Tregs. Consequently, targeted interventions aimed at modulating lipid metabolism in Tregs have been recognized as an innovative and promising approach to enhance the effectiveness of tumor immunotherapy. This review presents a comprehensive overview of the pivotal role of lipid metabolism in regulating the function of Tregs, with a specific focus on targeting Tregs lipid metabolism as an innovative approach to augment anti-tumor immune responses. Furthermore, we discuss potential opportunities and challenges associated with this strategy, aiming to provide novel insights for enhancing the efficacy of cancer immunotherapy.

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来源期刊

Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学

CiteScore

17.20

自引率

0.00%

发文量

138

审稿时长

33 days

期刊介绍： Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.