使用持续心脏监测评估心房颤动负担和模式对患者症状和医疗保健利用的影响：DEFINE AFib研究

IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Heart Rhythm O2 Pub Date : 2024-12-01 DOI:10.1016/j.hroo.2024.09.018

Dhanunjaya R. Lakkireddy MD , Andrea M. Russo MD , Elaine M. Hylek MD, MPH , Suneet Mittal MD , James Peacock MD, MS , Mellanie True Hills , Evan J. Stanelle MS, MA , Jeffrey D. Lande MS, PhD , Noreli C. Franco PhD , Lawrence C. Johnson PhD , Rahul Kanwar MS , Rod S. Passman MD, MHS , Jonathan P. Piccini MD, MHS

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引用次数: 0

摘要

背景：心房颤动（AF）对健康和生活质量有显著影响。房颤负担和房颤时间模式对患者症状、结果和医疗保健利用的关系尚不清楚。可插入式心脏监护仪（ICMs）是一种战略性的、尚未开发的工具，可以研究这些关系。目的：定义房颤（DEFINE AFib）研究将评估房颤负担和模式如何与房颤相关医疗保健利用（AFHCU）的变化和患者报告的生活质量相关。方法：这是一项前瞻性、观察性、多中心的研究，具有独特的设计，支持一种完整的方法来评估房颤作为一种多因素疾病。植入ICM的房颤患者将被纳入研究，并通过智能手机上基于应用程序的研究平台进行管理。患者将被远程监控，患者报告的结果将通过应用程序收集。AFHCU将通过参与者的医疗记录得到确认。结果：初步分析将评估ICMs收集的汇总和发作性测量是否与AFHCU的变化有关。次要分析将确定房颤特征与生活质量、房颤相关并发症的时间和严重程度、患者参与、患者报告结果的可靠性、来自其他数字心律检测器的数据以及护理质量和房颤cu的异质性之间的关系。结论：DEFINE AFib研究将为已知AF患者群体AF动态测量与AFHCU之间的关系提供有价值的见解。结果可能证明icm检测AF对患者预后的影响，并有助于分离预测临床风险的新型AF模式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Use of continuous cardiac monitoring to assess the influence of atrial fibrillation burden and patterns on patient symptoms and healthcare utilization: The DEFINE AFib study

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Use of continuous cardiac monitoring to assess the influence of atrial fibrillation burden and patterns on patient symptoms and healthcare utilization: The DEFINE AFib study

Background

Atrial fibrillation (AF) has a significant impact on health and quality of life. The relationship of AF burden and temporal patterns of AF on patient symptoms, outcomes, and healthcare utilization is unknown. Insertable cardiac monitors (ICMs) are a strategic and as yet untapped, tool to investigate these relationships.

Objective

The DEFINE Atrial Fibrillation (DEFINE AFib) study will evaluate how AF burden and patterns are associated with changes in AF-related healthcare utilization (AFHCU) and patient-reported quality of life.

Methods

This is a prospective, observational, multicenter study with a unique design that supports a complete method of assessing AF as a multifactorial disease. Patients with AF implanted with an ICM will be enrolled in the study and managed through an app-based research platform on their smartphone. Patients will be remotely monitored and patient-reported outcomes will be collected via the app. AFHCU will be confirmed via the participant’s medical record.

Results

The primary analysis will evaluate whether summary and episodic measurements collected by ICMs are associated with changes in AFHCU. Secondary analyses will determine the relationship between AF characteristics and quality of life, timing and severity of AF-related complications, patient engagement, reliability of patient-reported outcomes, data from other digital rhythm detectors, and heterogeneity in care quality and AFHCU.

Conclusion

The DEFINE AFib study will provide valuable insights into the association between dynamic measures of AF and AFHCU in a patient population with known AF. The results may demonstrate the impact of ICM-detected AF on patient outcomes and help isolate novel AF patterns predictive of clinical risk.

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来源期刊

Heart Rhythm O2 Cardiology and Cardiovascular Medicine

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

52 days