家庭暴露于药物滥用和癌症手术后新的持续阿片类药物使用的风险。

IF 2 3区医学 Q3 ONCOLOGY

Journal of Surgical Oncology Pub Date : 2025-01-13 DOI:10.1002/jso.28085

Mujtaba Khalil, Selamawit Woldesenbet, Shreya Shaw, Shahzaib Zindani, Zayed Rashid, Abdullah Altaf, Razeen Thammachack, Syed Husain, Timothy M Pawlik

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引用次数: 0

摘要

背景：家庭层面的因素也可能影响新的持续阿片类药物使用（NPOU）的风险。我们试图评估家庭暴露于药物滥用的个体发生NPOU的风险。方法：Opioid-naïve使用IBM MarketScan数据库识别接受肿瘤手术的个体。使用多变量回归方程来评估家庭药物滥用暴露与NPOU之间的关系。结果：10557人中有药物滥用家族史的占4.9% （n = 520）。有药物滥用家族史的患者在围手术期（85.0%对78.8%）和术后（40.2%对34.1%）更有可能使用阿片类药物（p均为p）。结论：在opioid-naïve接受肿瘤手术的个体中，药物滥用家族史与NPOU相关。在处方阿片类药物用于围手术期使用之前，应筛查患者的家庭因素。

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Household Exposure to Substance Abuse and the Risk of New Persistent Opioid Use After Cancer Surgery.

Background: Household-level factors may also influence the risk of new persistent opioid use (NPOU). We sought to assess the risk of NPOU among individuals with household exposure to substance abuse.

Methods: Opioid-naïve individuals who underwent oncological procedures were identified using the IBM MarketScan database. Multivariable regression equations were used to assess the association between household exposure to substance abuse and NPOU.

Results: Among 10 557 individuals 4.9% (n = 520) had a family history of substance abuse. Patients with a family history of substance abuse were more likely to use opioids during the perioperative (85.0% vs. 78.8%) and postoperative periods (40.2% vs. 34.1%) (both p < 0.05). Moreover, perioperative (300 MME [IQR: 450-200] vs. 250 MME [IQR: 150-435]) and postoperative (525 MME [IQR: 1348-225] vs. 350 MME [IQR: 150-850]) opioid dose was also higher among patients with a family history of substance abuse (both p < 0.001). On multivariate analysis, patients with family history of substance abuse had 37% (OR 1.37, 95% CI 1.07-1.75) higher odds of NPOU.

Conclusion: Among opioid-naïve individuals undergoing oncological procedures, a family history of substance abuse is associated with NPOU. Patients should be screened for household-level factors before prescribing opioids for perioperative use.

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来源期刊

Journal of Surgical Oncology 医学-外科

CiteScore

4.70

自引率

4.00%

发文量

367

审稿时长

2 months

期刊介绍： The Journal of Surgical Oncology offers peer-reviewed, original papers in the field of surgical oncology and broadly related surgical sciences, including reports on experimental and laboratory studies. As an international journal, the editors encourage participation from leading surgeons around the world. The JSO is the representative journal for the World Federation of Surgical Oncology Societies. Publishing 16 issues in 2 volumes each year, the journal accepts Research Articles, in-depth Reviews of timely interest, Letters to the Editor, and invited Editorials. Guest Editors from the JSO Editorial Board oversee multiple special Seminars issues each year. These Seminars include multifaceted Reviews on a particular topic or current issue in surgical oncology, which are invited from experts in the field.