肥大细胞生物学最新进展。

IF 11.4 1区医学 Q1 ALLERGY

Journal of Allergy and Clinical Immunology Pub Date : 2025-04-01 DOI:10.1016/j.jaci.2024.12.1092

Hadas Tamar Pahima PhD , Daniel F. Dwyer PhD

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引用次数: 0

摘要

肥大细胞（MCs）是异质组织驻留效应细胞，被认为在过敏性炎症疾病中发挥核心作用，但这些作用的异质性程度和性质仍然难以捉摸。近年来，组织培养系统、临床前小鼠模型的进步以及单细胞RNA测序的持续传播极大地促进了我们对MC在健康和疾病中的表型的理解。这些方法已经确定了MCs亚群与免疫细胞、神经元和组织结构细胞之间的新相互作用，改变了我们对MCs如何驱动和帮助解决组织炎症、重塑组织微环境和影响宿主行为的理解。本文综述了2022-2024年间的关键研究，这些研究促进了我们对小鼠和人类MC生物学的理解。

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Update on mast cell biology

Mast cells (MCs) are heterogeneous tissue-resident effector cells that are thought to play central roles in allergic inflammatory disease, yet the degree of heterogeneity and nature of these roles has remained elusive. In recent years, advances in tissue culture systems, preclinical mouse models, and the continued spread of single-cell RNA sequencing have greatly advanced our understanding of MC phenotypes in health and disease. These approaches have identified novel interactions of MC subsets with immune cells, neurons, and tissue structural cells, changing our understanding of how MCs both drive and help resolve tissue inflammation, reshape tissue microenvironments, and influence host behavior. This review addresses key studies from 2022 to 2024 that have advanced our understanding of MC biology in mice and humans.

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来源期刊

Journal of Allergy and Clinical Immunology 医学-过敏

CiteScore

25.90

自引率

7.70%

发文量

1302

审稿时长

38 days

期刊介绍： The Journal of Allergy and Clinical Immunology is a prestigious publication that features groundbreaking research in the fields of Allergy, Asthma, and Immunology. This influential journal publishes high-impact research papers that explore various topics, including asthma, food allergy, allergic rhinitis, atopic dermatitis, primary immune deficiencies, occupational and environmental allergy, and other allergic and immunologic diseases. The articles not only report on clinical trials and mechanistic studies but also provide insights into novel therapies, underlying mechanisms, and important discoveries that contribute to our understanding of these diseases. By sharing this valuable information, the journal aims to enhance the diagnosis and management of patients in the future.