{"title":"苯酚、对羟基苯甲酸酯和邻苯二甲酸酯与生物衰老的关系：2005-2010 年 NHANES 中按实际年龄和生活方式进行的分层分析。","authors":"Han Ma, Jinyue Li, Hanping Ma","doi":"10.1080/09603123.2025.2451626","DOIUrl":null,"url":null,"abstract":"<p><p>Humans are widely exposed to phenols, parabens, and phthalates with health risks, while the effects of these chemicals on biological aging remain unclear. Among 3,441 adults in the National Health and Nutrition Examination Survey 2005-2010, phenol, paraben, and phthalate concentrations were measured and phenotypic age acceleration (PhenoAgeAccel) was calculated. Linear regression and weighted quantile sum (WQS) regression were used to evaluate the associations of single and mixed chemicals with PhenoAgeAccel. Stratified analyses by chronological age and lifestyle were also performed. Individual phthalates were positively associated with PhenoAgeAccel. The WQS model found the positive relationship between mixed chemicals with PhenoAgeAccel (<i>β</i> = 0.175, 95%CI: 0.001, 0.349). The adverse impacts of phenols and phthalates on biological aging were stronger in older participants with significant interactions. Adherence to healthier lifestyle might partly reduce the positive relationships of phenols and phthalates with biological aging, especially among older adults, which is expected to be a viable intervention in the future.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-17"},"PeriodicalIF":2.2000,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Associations of phenols, parabens, and phthalates with biological aging: stratified analyses by chronological age and lifestyle in NHANES 2005-2010.\",\"authors\":\"Han Ma, Jinyue Li, Hanping Ma\",\"doi\":\"10.1080/09603123.2025.2451626\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Humans are widely exposed to phenols, parabens, and phthalates with health risks, while the effects of these chemicals on biological aging remain unclear. Among 3,441 adults in the National Health and Nutrition Examination Survey 2005-2010, phenol, paraben, and phthalate concentrations were measured and phenotypic age acceleration (PhenoAgeAccel) was calculated. Linear regression and weighted quantile sum (WQS) regression were used to evaluate the associations of single and mixed chemicals with PhenoAgeAccel. Stratified analyses by chronological age and lifestyle were also performed. Individual phthalates were positively associated with PhenoAgeAccel. The WQS model found the positive relationship between mixed chemicals with PhenoAgeAccel (<i>β</i> = 0.175, 95%CI: 0.001, 0.349). The adverse impacts of phenols and phthalates on biological aging were stronger in older participants with significant interactions. Adherence to healthier lifestyle might partly reduce the positive relationships of phenols and phthalates with biological aging, especially among older adults, which is expected to be a viable intervention in the future.</p>\",\"PeriodicalId\":14039,\"journal\":{\"name\":\"International Journal of Environmental Health Research\",\"volume\":\" \",\"pages\":\"1-17\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-01-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Environmental Health Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/09603123.2025.2451626\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Environmental Health Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/09603123.2025.2451626","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
Associations of phenols, parabens, and phthalates with biological aging: stratified analyses by chronological age and lifestyle in NHANES 2005-2010.
Humans are widely exposed to phenols, parabens, and phthalates with health risks, while the effects of these chemicals on biological aging remain unclear. Among 3,441 adults in the National Health and Nutrition Examination Survey 2005-2010, phenol, paraben, and phthalate concentrations were measured and phenotypic age acceleration (PhenoAgeAccel) was calculated. Linear regression and weighted quantile sum (WQS) regression were used to evaluate the associations of single and mixed chemicals with PhenoAgeAccel. Stratified analyses by chronological age and lifestyle were also performed. Individual phthalates were positively associated with PhenoAgeAccel. The WQS model found the positive relationship between mixed chemicals with PhenoAgeAccel (β = 0.175, 95%CI: 0.001, 0.349). The adverse impacts of phenols and phthalates on biological aging were stronger in older participants with significant interactions. Adherence to healthier lifestyle might partly reduce the positive relationships of phenols and phthalates with biological aging, especially among older adults, which is expected to be a viable intervention in the future.
期刊介绍：
International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.
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