不同诊断标准下甘油三酯血糖指数与高血压的关系

IF 2.1 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of General Medicine Pub Date : 2025-01-06 eCollection Date: 2025-01-01 DOI:10.2147/IJGM.S499194

Hua Hao, Hui Geng, Mao Ma

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引用次数: 0

摘要

目的探讨不同诊断阈值下甘油三酯血糖指数（TyG）与高血压的关系：本研究分析了西安交通大学第一附属医院 2019 年进行的常规职业健康检查数据。采用甘油三酯（TG）、空腹血糖（FPG）和体重指数（BMI）计算胰岛素抵抗（IR）指标TyG和TyG-BMI。高血压以 140/90 mmHg 和 130/80 mmHg 为临界值。采用逻辑回归模型研究 TyG 与高血压之间的关系：结果：在4028名受试者中，调整协变量后，TyG的Q4组与Q1组相比，患高血压（以140/90 mmHg为诊断标准）的风险高出2.87倍（OR=2.87，95% CI：2.11-3.91）。同样，TyG-BMI 第 4 季度组的风险是第 1 季度组的 8.03 倍（OR=8.03，95% CI：5.05-12.75）。此外，与 Q1 组相比，TyG 的 Q4 组患高血压（以 130/80 mmHg 为诊断标准）的风险高出 2.93 倍（OR=2.93，95% CI：2.34-3.68），TyG-BMI 的 Q4 组比 Q1 组高出 7.12 倍（OR=7.12，95% CI：5.08-9.99）。限制性立方样条进一步显示，TyG/ TyG-BMI 与高血压之间存在剂量-反应关系。在体重指数为24.0-27.9 kg/m2的人群中，TyG的Q4组患高血压（诊断为140/90 mmHg）的风险是Q1组的2.79倍（OR=2.79，95% CI：1.67-4.66），而TyG的Q4组患高血压（诊断为130/80 mmHg）的风险是Q1组的3.07倍（OR=3.07，95% CI：2.05-4.60）：TyG是不同阈值下高血压的独立风险因素，显示出明显的剂量-反应关系。体重指数（BMI）可能会影响这种关联，这强调了早期控制胰岛素抵抗以帮助预防高血压的重要性。

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Association Between Triglyceride Glucose Index and Hypertension According to Different Diagnostic Criteria.

Objective: To explore the association between triglyceride glucose index (TyG) and hypertension under different diagnostic thresholds.

Methods: This study analyzed data from routine occupational health examinations conducted at the First Affiliated Hospital of Xi'an Jiaotong University in 2019. TyG and TyG-BMI, indicators of insulin resistance (IR), were calculated using triglyceride (TG), fasting blood glucose (FPG), and body mass index (BMI). Hypertension was defined by thresholds of 140/90 mmHg and 130/80 mmHg. Logistic regression models were employed to investigate the association between TyG and hypertension.

Results: Among 4028 subjects, after adjusting for covariates, the risk of hypertension (diagnosed by 140/90 mmHg) was 2.87 times higher (OR=2.87, 95% CI: 2.11-3.91) in the Q4 group of TyG compared to the Q1 group. Similarly, the risk was 8.03 times higher (OR=8.03, 95% CI: 5.05-12.75) in the Q4 group of TyG-BMI than in the Q1 group. Furthermore, the risk of hypertension (diagnosed by 130/80 mmHg) was 2.93 times higher (OR=2.93, 95% CI: 2.34-3.68) in the Q4 group of TyG compared to the Q1 group, and 7.12 times higher (OR=7.12, 95% CI: 5.08-9.99) in the Q4 group of TyG-BMI than in the Q1 group. The restricted cubic spline further showed a dose-response relationship between TyG/ TyG-BMI and hypertension. In the population with a BMI of 24.0-27.9 kg/m², the risk of developing hypertension (diagnosed by 140/90 mmHg) in the Q4 group of TyG was 2.79 times higher (OR=2.79, 95% CI: 1.67-4.66), while the Q4 group with TyG had a 3.07 times greater risk of hypertension (diagnosed by 130/80 mmHg) than the Q1 group (OR=3.07, 95% CI: 2.05-4.60).

Conclusion: TyG is an independent risk factor for hypertension across different thresholds, showing a clear dose-response relationship. BMI may influence this association, emphasizing the importance of managing insulin resistance early to aid hypertension prevention.

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来源期刊

International Journal of General Medicine Medicine-General Medicine

自引率

0.00%

发文量

1113

审稿时长

16 weeks

期刊介绍： The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.