慢性低度炎症在肌肉减少症发生中的作用：分子机制的进展。

IF 4.8 2区医学 Q2 IMMUNOLOGY

International immunopharmacology Pub Date : 2025-02-06 DOI:10.1016/j.intimp.2025.114056

Ying Cheng , Shangjin Lin , Ziyi Cao , Runzhi Yu , Yongqian Fan , Jie Chen

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引用次数: 0

摘要

随着全球人口老龄化的加剧，肌肉减少症已日益成为公认的公共卫生问题。骨骼肌减少症以骨骼肌质量、力量和功能的逐渐下降为特征，严重影响老年人的生活质量。在此，我们探讨慢性炎症在肌肉减少症发展中的作用及其潜在的分子机制，包括慢性炎症相关的信号通路，免疫衰老，肥胖和脂质浸润，肠道微生物群失调和肠道屏障破坏，以及卫星细胞的下降。这些分子机制的相互作用和相互作用为研究肌肉减少症发病机制的复杂性提供了新的视角，并为未来治疗策略的发展提供了理论基础。

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The role of chronic low-grade inflammation in the development of sarcopenia: Advances in molecular mechanisms

With the exacerbation of global population aging, sarcopenia has become an increasingly recognized public health issue. Sarcopenia, characterized by a progressive decline in skeletal muscle mass, strength, and function, significantly impacts the quality of life in the elderly. Herein, we explore the role of chronic low-grade inflammation in the development of sarcopenia and its underlying molecular mechanisms, including chronic inflammation-associated signaling pathways, immunosenescence, obesity and lipid infiltration, gut microbiota dysbiosis and intestinal barrier disruption, and the decline of satellite cells. The interplay and interaction of these molecular mechanisms provide new perspectives on the complexity of the pathogenesis of sarcopenia and offer a theoretical foundation for the development of future therapeutic strategies.

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来源期刊

International immunopharmacology 医学-免疫学

CiteScore

8.40

自引率

3.60%

发文量

935

审稿时长

53 days

期刊介绍： International Immunopharmacology is the primary vehicle for the publication of original research papers pertinent to the overlapping areas of immunology, pharmacology, cytokine biology, immunotherapy, immunopathology and immunotoxicology. Review articles that encompass these subjects are also welcome. The subject material appropriate for submission includes: • Clinical studies employing immunotherapy of any type including the use of: bacterial and chemical agents; thymic hormones, interferon, lymphokines, etc., in transplantation and diseases such as cancer, immunodeficiency, chronic infection and allergic, inflammatory or autoimmune disorders. • Studies on the mechanisms of action of these agents for specific parameters of immune competence as well as the overall clinical state. • Pre-clinical animal studies and in vitro studies on mechanisms of action with immunopotentiators, immunomodulators, immunoadjuvants and other pharmacological agents active on cells participating in immune or allergic responses. • Pharmacological compounds, microbial products and toxicological agents that affect the lymphoid system, and their mechanisms of action. • Agents that activate genes or modify transcription and translation within the immune response. • Substances activated, generated, or released through immunologic or related pathways that are pharmacologically active. • Production, function and regulation of cytokines and their receptors. • Classical pharmacological studies on the effects of chemokines and bioactive factors released during immunological reactions.