Fujian Chen, Huan Zhou, Tingxia Zhang, Liangxue Wang, Hongfang Chen, Jin Hu, Guomin Xie, Shenqiang Yan, Min Lou, CASE-II Investigators
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Propensity score matching (PSM) analyses were employed.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>A total of 21,349 patients were included in this study, with a mean age of 68.5 ± 12.6 years, of whom 13,578 (63.6%) were male. The baseline NIHSS score was 4 (IQR 2–8). A total of 9532 patients (44.6%) received intensive statin therapy. In the PSM analysis, the proportion of patients with mRS scores of 0–2 was significantly higher in the intensive statin therapy group (OR = 1.095, 95% CI 1.022–1.173, <i>p</i> = 0.010). Statin type modified the effect of intensive statin therapy on functional independence (<i>p</i>-value for interaction = 0.030). 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引用次数: 0
摘要
目的：本研究旨在探讨急性缺血性卒中（AIS）患者静脉溶栓（IVT）后早期强化他汀类药物治疗的疗效。方法：从多中心注册数据库中纳入接受IVT和他汀类药物治疗的AIS患者。主要终点是功能独立性，由90天时修改的Rankin量表（mRS）评分0-2来定义。采用倾向得分匹配（PSM）分析。结果：共纳入21349例患者，平均年龄68.5±12.6岁，其中男性13578例（63.6%）。基线NIHSS评分为4 （IQR 2-8）。9532例患者（44.6%）接受了强化他汀类药物治疗。在PSM分析中，mr评分为0-2分的患者比例在他汀类药物强化治疗组明显更高（OR = 1.095, 95% CI 1.022-1.173, p = 0.010）。他汀类药物类型改变了他汀类药物强化治疗对功能独立性的影响（相互作用的p值= 0.030）。在接受阿托伐他汀治疗的患者中，观察到强化治疗的效果（OR = 1.134, 95% CI 1.051-1.224, p = 0.001）。结论：IVT后早期强化他汀类药物治疗可显著但适度改善神经系统预后，特别是在将阿托伐他汀作为强化治疗方案一部分的患者中。
The Efficacy of Intensive Statin Therapy in Acute Ischemic Stroke Following Intravenous Thrombolysis: The CASE II Study
Aims
This study aimed to investigate the efficacy of early intensive statin therapy following intravenous thrombolysis (IVT) in patients with acute ischemic stroke (AIS).
Methods
AIS patients who received IVT and statin therapy were included from multicenter registry databases. The primary endpoint was functional independence, defined by a modified Rankin Scale (mRS) score of 0–2 at 90 days. Propensity score matching (PSM) analyses were employed.
Results
A total of 21,349 patients were included in this study, with a mean age of 68.5 ± 12.6 years, of whom 13,578 (63.6%) were male. The baseline NIHSS score was 4 (IQR 2–8). A total of 9532 patients (44.6%) received intensive statin therapy. In the PSM analysis, the proportion of patients with mRS scores of 0–2 was significantly higher in the intensive statin therapy group (OR = 1.095, 95% CI 1.022–1.173, p = 0.010). Statin type modified the effect of intensive statin therapy on functional independence (p-value for interaction = 0.030). Treatment effects favoring the intensive approach were observed in patients receiving atorvastatin (OR = 1.134, 95% CI 1.051–1.224, p = 0.001).
Conclusion
Early intensive statin therapy following IVT leads to a significant but modest improvement in neurological outcomes, particularly in patients treated with atorvastatin as part of the intensive regimen.
期刊介绍：
CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.
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