基于天然蛋白的多功能水凝胶敷料，通过快速光固化和锌离子配合形成，加速伤口愈合

IF 8.2 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Materials & Interfaces Pub Date : 2025-01-13 DOI:10.1021/acsami.4c16083

Qiujiang Li, Yi Hou, Dan Sun, Ce Zhu, Ruibang Wu, Ganjun Feng, Li Zhang, Yueming Song

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引用次数: 0

摘要

本研究探讨了使用富含天然蛋白质的蛋清（EW）来解决伤口愈合管理中的挑战。本文开发了一种新型的注入Zn2+的EW/GelMA （EW/Gel）杂化水凝胶，具有互穿网络（IPN）结构，其中第一个网络由光交联的GelMA组成，第二个网络由注入Zn2+的EW （Zn-EW）通过离子蛋白结合组成。通过优化设计和配方，得到的Zn-EW/Gel水凝胶具有更好的机械稳定性和自粘性能。体外实验表明，Zn-EW/Gel水凝胶内功能蛋白和活性离子的联合作用可促进成纤维细胞增殖和I型胶原的表达，调节免疫微环境，促进血管生成。该水凝胶在体内也表现出了良好的生物相容性和生物活性，在恢复受损伤口组织的生理特性方面表现出了很强的希望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Natural Protein-Based Multifunctional Hydrogel Dressing Formed by Rapid Photocuring and Zinc Ion Coordination to Accelerate Wound Healing

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Natural Protein-Based Multifunctional Hydrogel Dressing Formed by Rapid Photocuring and Zinc Ion Coordination to Accelerate Wound Healing

This study explores the use of chicken egg white (EW), a rich source of natural proteins, to address challenges in wound healing management. Herein, a novel Zn²⁺-infused EW/GelMA (EW/Gel) hybrid hydrogel is developed, featuring an interpenetrating network (IPN) structure, where the first network consists of photo-cross-linked GelMA and the second network consists of Zn²⁺-infused EW (Zn-EW) through ion–protein binding. By optimizing the design and formulation, the resulting Zn-EW/Gel hydrogel exhibited enhanced mechanical stability and self-adhesive properties. In vitro experiments demonstrated that the combined effects of functional proteins and active ions within the Zn-EW/Gel hydrogel promote fibroblast proliferation and type I collagen expression, modulate the immune microenvironment, and enhance angiogenesis. The hydrogel also demonstrated excellent biocompatibility and bioactivity in vivo, showing strong promise for restoring the physiological properties of the damaged wound tissue.

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来源期刊

ACS Applied Materials & Interfaces 工程技术-材料科学：综合

CiteScore

16.00

自引率

6.30%

发文量

4978

审稿时长

1.8 months

期刊介绍： ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.