超临界co2辅助浸渍/沉积制备布洛芬负载明胶-硅氧烷凝胶，用于药物控释和组织工程

IF 3.4 3区工程技术 Q2 CHEMISTRY, PHYSICAL

Journal of Supercritical Fluids Pub Date : 2024-12-30 DOI:10.1016/j.supflu.2024.106511

Ulisses Silva do Nascimento , Carolina Kafka Neves , Erik Felix dos Santos , Chekwube Andrew Ezegbe , Laurent Rodrigues Rezende , Juliana Marchi , Christiane Bertachini Lombello , Lígia Passos Maia-Obi

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引用次数: 0

摘要

明胶基凝胶适用于生物医学应用，主要由于其形态，有可能使用scCO2浸渍。为了获得适用于药物控释和组织工程的装载布洛芬的明胶硅氧烷冷冻材料，在25 MPa和35℃的scCO2条件下，通过改变其浓度和助溶剂的量，研究了该药物在低温和干凝胶中的浸渍/沉积。通过FTIR， SEM，药物释放和细胞毒性研究对所得样品进行评价。对于干凝胶，布洛芬分散在基质中，而对于低温凝胶，布洛芬以片状颗粒的形式沉积在其孔隙中，从而呈现更高的药物负荷。增加布洛芬浓度，用3 %v/v的助溶剂，可增加载药量。在载药量足够的情况下，凝胶有较好的缓释作用，且无明显的细胞毒性，表明该凝胶可作为多功能支架使用。

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Ibuprofen loaded gelatin-siloxane gels prepared by supercritical CO2-assisted impregnation/deposition for controlled drug release and tissue engineering

Gelatin-based gels are suitable for biomedical applications and have potential to be impregnated using scCO₂ thanks mainly to their morphology. Aiming to obtain ibuprofen loaded gelatin-siloxane cryogels suitable for controlled drug release and tissue engineering, the impregnation/deposition of the drug was studied in both cryogels and xerogels in scCO₂ at 25 MPa and 35 °C, by varying its concentrations and the amount of co-solvent. The obtained samples were evaluated by FTIR, SEM, drug release and cytotoxicity studies. For the xerogels, the ibuprofen dispersed in the matrix, while for cryogels, additionally, it was deposited as flake-like particles inside their pores, thus presenting a higher drug load. Increasing the ibuprofen concentration and using 3 %v/v of co-solvent, increases the drug load. An extended release was observed for gels with sufficient drug load and no significative cytotoxicity was observed, showing that these gels can be applied as multifunctional scaffolds.

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来源期刊

Journal of Supercritical Fluids 工程技术-工程：化工

CiteScore

7.60

自引率

10.30%

发文量

236

审稿时长

56 days

期刊介绍： The Journal of Supercritical Fluids is an international journal devoted to the fundamental and applied aspects of supercritical fluids and processes. Its aim is to provide a focused platform for academic and industrial researchers to report their findings and to have ready access to the advances in this rapidly growing field. Its coverage is multidisciplinary and includes both basic and applied topics. Thermodynamics and phase equilibria, reaction kinetics and rate processes, thermal and transport properties, and all topics related to processing such as separations (extraction, fractionation, purification, chromatography) nucleation and impregnation are within the scope. Accounts of specific engineering applications such as those encountered in food, fuel, natural products, minerals, pharmaceuticals and polymer industries are included. Topics related to high pressure equipment design, analytical techniques, sensors, and process control methodologies are also within the scope of the journal.