采用GPR75治疗肥胖：揭开这种孤儿GPCR的已知和未知。

IF 13 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2025-02-01 Epub Date: 2025-01-09 DOI:10.1016/j.tcb.2024.12.006

Yiao Jiang, Zhao Zhang

引用次数: 0

摘要

G蛋白偶联受体75 （GPR75）正在成为肥胖治疗的一个有希望的靶点，但其在能量调节中的确切作用尚不清楚。本文探讨了GPR75的分子功能、潜在配体和治疗肥胖挑战的最新研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Adopting GPR75 in treating obesity: unraveling the knowns and unknowns of this orphan GPCR.

G protein-coupled receptor 75 (GPR75) is emerging as a promising target for obesity treatment, but its exact role in energy regulation remains unclear. This article explores the latest research on GPR75's molecular function, potential ligands, and therapeutic challenges in addressing obesity.

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.