耐药胃腺鳞癌的类器官模型：概括肿瘤特征并改进精准治疗。

IF 15.8 1区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Resistance Updates Pub Date : 2025-01-07 DOI:10.1016/j.drup.2025.101201

Kuan Li, Wenchao Li, Shuying Fu, Chen Wang, Kexin Wang, Huan Yang, Yumei Xian, Tengfei Hao, Shiwei Zhang, Tianshun Gao, Jie Zhou, Jia Li, Changhua Zhang, Wei Chen, Leli Zeng, Yulong He

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引用次数: 0

摘要

我们成功地从患者的原发肿瘤及其转移淋巴结中建立了类器官。这些类器官忠实地复制了肿瘤的病理和遗传特征。我们进行了基于类器官的药物筛选，发现来自原发肿瘤的类器官与来自转移性淋巴结的类器官对药物的敏感性存在显著差异。结果指导临床决策的个性化治疗的病人。这种方法为推进胃癌的治疗提供了一种有见地的策略。

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Organoid models of drug resistant gastric adenosquamous carcinoma: Recapitulating tumor features and refining precision treatment.

Organoids were successfully established from primary tumor and its metastatic lymph nodes of a patient. These organoids faithfully replicated tumor pathology and genetic characteristics. Organoid-based drug screening was conducted, which revealed significant difference in sensitivity to drugs between organoids dervived from primary tumor versus metastatic lymph nodes. The results guided clinical decisions for personalized treatment for the patient. This approach provides an insightful strategy for advancing treatment for gastric cancer.

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来源期刊

Drug Resistance Updates 医学-药学

CiteScore

26.20

自引率

11.90%

发文量

审稿时长

29 days

期刊介绍： Drug Resistance Updates serves as a platform for publishing original research, commentary, and expert reviews on significant advancements in drug resistance related to infectious diseases and cancer. It encompasses diverse disciplines such as molecular biology, biochemistry, cell biology, pharmacology, microbiology, preclinical therapeutics, oncology, and clinical medicine. The journal addresses both basic research and clinical aspects of drug resistance, providing insights into novel drugs and strategies to overcome resistance. Original research articles are welcomed, and review articles are authored by leaders in the field by invitation. Articles are written by leaders in the field, in response to an invitation from the Editors, and are peer-reviewed prior to publication. Articles are clear, readable, and up-to-date, suitable for a multidisciplinary readership and include schematic diagrams and other illustrations conveying the major points of the article. The goal is to highlight recent areas of growth and put them in perspective. *Expert reviews in clinical and basic drug resistance research in oncology and infectious disease *Describes emerging technologies and therapies, particularly those that overcome drug resistance *Emphasises common themes in microbial and cancer research