内源性因子对热色氨酸的调节及其在核心体温下的生理功能。

IF 2.2 Q3 PHYSIOLOGY

Physiological Reports Pub Date : 2025-01-01 DOI:10.14814/phy2.70164

Makiko Kashio

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引用次数: 0

摘要

具有温度敏感性的瞬时受体电位（Transient receptor potential， TRP）通道参与多种生理过程。在哺乳动物中，检测外周感觉神经元温度变化的热trp在热感觉中具有不可缺少的功能，引发对有害温度的防御行为，并驱动自主/行为热调节反应以维持体温。此外，大多数热trps在温度维持在恒定核心体温的细胞和组织中功能表达。为了发挥生理功能，每个热trp通道的活性必须受到体温内源性机制的调节。这一过程的失调会导致各种疾病。本文综述了恒定核心体温下调节热trp活性的内源性因素及其生理功能。

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Thermo-TRP regulation by endogenous factors and its physiological function at core body temperature.

Transient receptor potential (TRP) channels with temperature sensitivities (thermo-TRPs) are involved in various physiological processes. Thermo-TRPs that detect temperature changes in peripheral sensory neurons possess indispensable functions in thermosensation, eliciting defensive behavior against noxious temperatures and driving autonomic/behavioral thermoregulatory responses to maintain body temperature in mammals. Moreover, most thermo-TRPs are functionally expressed in cells and tissues where the temperature is maintained at a constant core body temperature. To perform physiological functions, the activity of each thermo-TRP channel must be regulated by endogenous mechanisms at body temperature. Dysregulation of this process can lead to various diseases. This review highlights the endogenous factors regulating thermo-TRP activity and physiological functions at constant core body temperature.

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来源期刊

Physiological Reports PHYSIOLOGY-

CiteScore

4.20

自引率

4.00%

发文量

374

审稿时长

9 weeks

期刊介绍： Physiological Reports is an online only, open access journal that will publish peer reviewed research across all areas of basic, translational, and clinical physiology and allied disciplines. Physiological Reports is a collaboration between The Physiological Society and the American Physiological Society, and is therefore in a unique position to serve the international physiology community through quick time to publication while upholding a quality standard of sound research that constitutes a useful contribution to the field.