青春期后红细胞肌酸升高与红细胞寿命无关：HbA1c与红细胞肌酸缺乏相关性的意义。

IF 3.2 3区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Clinica Chimica Acta Pub Date : 2025-01-08 DOI:10.1016/j.cca.2025.120130

Takahide Kokumai , Shigeru Suzuki , Satoru Takahashi , Toshika Okumiya , Masafumi Koga

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引用次数: 0

摘要

背景：HbA1c水平受血糖和红细胞寿命的影响。红细胞肌酸（EC）表示红细胞平均年龄。尽管青春期男性和女性的EC水平不同，但女性的EC水平较高，其机制尚不清楚。我们检查了非糖尿病儿童的EC和HbA1c水平。方法：本研究纳入85名无糖尿病或贫血的3-18岁 儿童（男/女：44/41）。测量EC、年龄、HbA1c、糖化白蛋白（GA）、随机血糖（PG）和全血细胞计数的数据。我们分别检查了男性和女性EC、年龄和HbA1c水平之间的相关性。此外，我们比较了有月经和没有月经的女性。结果：年龄、EC、HbA1c、GA和PG水平在两性之间具有可比性。两组患者的HbA1c水平均与年龄无关(男性：R = 0.063,p = 0.684；女性：R = 0.112,p = 0.486)。男性EC水平与年龄无关（R = 0.089,p = 0.567），与HbA1c呈负相关（R = 0.281,p = 0.065）。在女性中，EC水平与年龄呈正相关（R = 0.557,p ）。结论：在非糖尿病和非贫血儿童中，EC与HbA1c水平无显著相关性。然而，在女性中观察到HbA1c和EC水平与年龄相关的差异。这些发现表明，在女性中，而不是在男性中，EC可能与青春期后红细胞寿命无关。

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Elevation of erythrocyte creatine post-puberty unrelated to erythrocyte lifespan: Implications from the lack of correlation between HbA1c and erythrocyte creatine

Background

HbA1c levels are affected by both glycemia and erythrocyte lifespan. Erythrocyte creatine (EC) indicates mean erythrocyte age. Although EC levels differ between adolescent males and females, with higher levels in females, the mechanism remains unclear. We examined the EC and HbA1c levels in non-diabetic children.

Methods

This study included 85 children aged 3–18 years (male/female: 44/41) without diabetes or anemia. Data on EC, age, HbA1c, glycated albumin (GA), casual plasma glucose (PG), and complete blood count were measured. We examined correlation among EC, age, and HbA1c levels separately in males and females. Additionally, we compared women with and without menstruation.

Results

Age, EC, HbA1c, GA, and PG levels were comparable between the sexes. HbA1c levels were not correlated with age in either group (males: R = 0.063, p = 0.684; females: R = 0.112, p = 0.486). In males, EC levels were not correlated with age (R = 0.089, p = 0.567), but showed a negative trend with HbA1c (R = 0.281, p = 0.065). In females, EC levels were positively correlated with age (R = 0.557, p < 0.001), but not with HbA1c (R = 0.140, p = 0.383). Females with menstruation had higher EC levels (1.64 ± 0.43 µmol/g Hb) than those without menstruation (1.23 ± 0.23 µmol/g Hb, p = 0.004): however, HbA1c differences were not significant (5.44 ± 0.28 % vs, 5.41 ± 0.22 %, p = 0.771).

Conclusions

No significant correlation was observed between EC and HbA1c levels in non-diabetic and non-anemic children. However, the discrepancy between HbA1c and EC levels in relation to age in females was observed. These findings indicate that in females, but not in males, EC may be falsely elevated irrespective of erythrocyte lifespan after puberty.

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来源期刊

Clinica Chimica Acta 医学-医学实验技术

CiteScore

10.10

自引率

2.00%

发文量

1268

审稿时长

23 days

期刊介绍： The Official Journal of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Clinica Chimica Acta is a high-quality journal which publishes original Research Communications in the field of clinical chemistry and laboratory medicine, defined as the diagnostic application of chemistry, biochemistry, immunochemistry, biochemical aspects of hematology, toxicology, and molecular biology to the study of human disease in body fluids and cells. The objective of the journal is to publish novel information leading to a better understanding of biological mechanisms of human diseases, their prevention, diagnosis, and patient management. Reports of an applied clinical character are also welcome. Papers concerned with normal metabolic processes or with constituents of normal cells or body fluids, such as reports of experimental or clinical studies in animals, are only considered when they are clearly and directly relevant to human disease. Evaluation of commercial products have a low priority for publication, unless they are novel or represent a technological breakthrough. Studies dealing with effects of drugs and natural products and studies dealing with the redox status in various diseases are not within the journal''s scope. Development and evaluation of novel analytical methodologies where applicable to diagnostic clinical chemistry and laboratory medicine, including point-of-care testing, and topics on laboratory management and informatics will also be considered. Studies focused on emerging diagnostic technologies and (big) data analysis procedures including digitalization, mobile Health, and artificial Intelligence applied to Laboratory Medicine are also of interest.