先前住院儿童中与ADHD相关的生理和神经生理成熟:一项随机对照试验。

IF 6.5 1区 医学 Q1 PSYCHIATRY
Anne B Arnett, Martín Antúnez, Charles Zeanah, Nathan A Fox, Charles A Nelson
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引用次数: 0

摘要

背景:注意缺陷多动障碍(ADHD)是早期机构护理史儿童中常见的神经发育结果。先前对收容儿童的研究表明,儿童时期加速的身体发育是ADHD结果的一个风险因素。方法:目前的研究检查了在布加勒斯特早期干预项目(NCT00747396, clinicaltrials.gov)中随机分配到寄养治疗(n = 59)或正常护理(n = 54)和未住院儿童(n = 64)的机构儿童的身体和神经生理生长轨迹。参与者在从婴儿期到青春期的六个时间点完成了身体和脑电图(EEG)评估,并在54个月和12岁的时间点进行了结构化的诊断访谈。我们估计了一系列的多层次生长模型和交叉滞后路径模型,以检验身体和神经生理成熟度、治疗组、寄养安置年龄和ADHD诊断结果之间的关系。结果:27%的住院儿童在一个或两个时间点符合ADHD的研究标准。身高和头围生长缓慢、延长与ADHD和寄养安置延迟有关。寄养与正常护理,但不包括多动症,与α峰值频率的成熟有关。在随机分配到寄养家庭的儿童中,患有多动症的儿童的平均β -比值较低。没有证据表明快速的生理成熟导致非典型的皮质活动。结论:在机构儿童中,从婴儿期到青春期的延迟、延长的身体发育和不典型的神经生理与ADHD相关,超过寄养的保护作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Physical and neurophysiological maturation associated with ADHD among previously institutionalized children: a randomized controlled trial.

Background: Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental outcome among children with a history of early institutional care. Prior research on institutionalized children suggested that accelerated physical growth in childhood is a risk factor for ADHD outcomes.

Methods: The current study examined physical and neurophysiological growth trajectories among institutionalized children randomized to foster care treatment (n = 59) or care as usual (n = 54), and never institutionalized children (n = 64) enrolled in the Bucharest Early Intervention Project (NCT00747396, clinicaltrials.gov). Participants completed physical and electroencephalography (EEG) assessments at six time points from infancy through adolescence, as well as structured diagnostic interviews at the 54-month and 12-year time points. A series of multilevel growth models and cross-lagged path models were estimated to examine associations among physical and neurophysiological maturation, treatment group, age of foster care placement, and ADHD diagnostic outcomes.

Results: Twenty-seven percent of the institutionalized children met research criteria for ADHD at one or both time points. Slowed, prolonged growth of height and head circumference were associated with both ADHD and delayed foster care placement. Placement in foster care versus care as usual, but not ADHD, was associated with maturation of the peak alpha frequency. Among children randomized to foster care, average theta-beta ratio was lower among those with ADHD. There was no evidence that rapid physical maturation led to atypical cortical activity.

Conclusions: Delayed, prolonged physical growth and atypical neurophysiology from infancy through adolescence is associated with ADHD among institutionalized children, over and above the protective effects of foster care.

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来源期刊
CiteScore
13.80
自引率
5.30%
发文量
169
审稿时长
1 months
期刊介绍: The Journal of Child Psychology and Psychiatry (JCPP) is a highly regarded international publication that focuses on the fields of child and adolescent psychology and psychiatry. It is recognized for publishing top-tier, clinically relevant research across various disciplines related to these areas. JCPP has a broad global readership and covers a diverse range of topics, including: Epidemiology: Studies on the prevalence and distribution of mental health issues in children and adolescents. Diagnosis: Research on the identification and classification of childhood disorders. Treatments: Psychotherapeutic and psychopharmacological interventions for child and adolescent mental health. Behavior and Cognition: Studies on the behavioral and cognitive aspects of childhood disorders. Neuroscience and Neurobiology: Research on the neural and biological underpinnings of child mental health. Genetics: Genetic factors contributing to the development of childhood disorders. JCPP serves as a platform for integrating empirical research, clinical studies, and high-quality reviews from diverse perspectives, theoretical viewpoints, and disciplines. This interdisciplinary approach is a key feature of the journal, as it fosters a comprehensive understanding of child and adolescent mental health. The Journal of Child Psychology and Psychiatry is published 12 times a year and is affiliated with the Association for Child and Adolescent Mental Health (ACAMH), which supports the journal's mission to advance knowledge and practice in the field of child and adolescent mental health.
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