fof1 - atp酶生物分子运动：结构、运动操纵和生物医学应用。

IF 5.5 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules Pub Date : 2025-01-11 DOI:10.1021/acs.biomac.4c01553

Xuhui Zhou, Miao Sun, Xiu Yang, Mengliu Shao, Mengya Jin, Yuanbin She, Qingliang Yang, Gensheng Yang

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引用次数: 0

摘要

生物分子马达是存在于生物体中具有高能量转换效率的动力系统。fof1 - atp酶是一种旋转生物分子马达，以其接近100%的能量转换效率而闻名。它利用ATP的合成和水解来诱导运动蛋白的构象变化，从而将化学能转化为机械运动。由于其高效率、自主推进能力和可修改的结构，fof1 - atp酶马达在潜在的生物医学应用中引起了极大的关注。本文旨在介绍fof1 - atp酶的详细结构，探讨各种运动控制策略，并总结其在生物检测和货物运输中的应用。并提出创新的研究方法，更全面地分析fof1 - atp酶的运动机制，推动其在生物医学上的应用。最后，本综述总结了关键的见解和未来的展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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F_OF₁-ATPase Biomolecular Motor: Structure, Motility Manipulations, and Biomedical Applications.

Biomolecular motors are dynamic systems found in organisms with high energy conversion efficiency. F_OF₁-ATPase is a rotary biomolecular motor known for its near 100% energy conversion efficiency. It utilizes the synthesis and hydrolysis of ATP to induce conformational changes in motor proteins, thereby converting chemical energy into mechanical motion. Given their high efficiency, autonomous propulsion capability, and modifiable structures, F_OF₁-ATPase motors have attracted significant attention for potential biomedical applications. This Review aims to introduce the detailed structure of F_OF₁-ATPase, explore various motility manipulation strategies, and summarize its applications in biological detection and cargo delivery. Additionally, innovative research methods are proposed to analyze the motion mechanism of F_OF₁-ATPase more comprehensively, with the goal of advancing its biomedical applications. Finally, this Review concludes with key insights and future perspectives.

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来源期刊

Biomacromolecules 化学-高分子科学

CiteScore

10.60

自引率

4.80%

发文量

417

审稿时长

1.6 months

期刊介绍： Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.