瞬态定向基团辅助钯催化吲哚的c4 -炔基化反应

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-01-10 DOI:10.1021/acs.joc.4c02478

Shuqi Guo, Huanfeng Jiang, Shaorong Yang, Wanqing Wu

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引用次数: 0

摘要

以甘氨酸为瞬时导向基团，建立了pd催化吲哚的c4选择性烷基化反应。该反应具有高度的区域选择性和广泛的官能团的耐受性，以中等到良好的收率提供不同的烷基化吲哚。此外，易于获得的放大合成和进一步修饰以实现多功能化吲哚，证明了该方案的合成潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Transient Directing Group-Assisted Palladium-Catalyzed C4-Alkynylation of Indoles

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Transient Directing Group-Assisted Palladium-Catalyzed C4-Alkynylation of Indoles

Pd-catalyzed C4-selective alkynylation of indoles was established by employing glycine as a transient directing group. This reaction exhibits high regioselectivity with the tolerance of a wide scope of functional groups to afford diverse alkynylated indoles in moderate to good yields. Moreover, the readily accessible scale-up synthesis and further decorations to achieve multifunctionalized indoles demonstrate the synthetic potential of this protocol.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.