复杂相互作用：柑橘tristeza病毒与其宿主之间的相互作用。

IF 2.8 3区医学 Q3 VIROLOGY

Virology Pub Date : 2025-02-01 DOI:10.1016/j.virol.2024.110388

Maryam Khalilzadeh , Dirk Jacobus Aldrich , Hans Jacob Maree , Amit Levy

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引用次数: 0

摘要

柑橘tristeza病毒（Citrus tristeza virus， CTV）是侵染植物的最大和最具经济价值的RNA病毒之一。CTV与多种柑橘寄主的相互作用可导致三种疾病：快速衰退，茎蚀或幼苗黄。由于CTV具有显著的遗传多样性和不同基因型感染不同柑橘宿主时疾病症状的高度特异性，因此研究CTV带来了一些挑战。在功能表征参与CTV三种疾病诱导的病毒-宿主相互作用方面已经取得了相当大的进展，揭示了四种CTV orf （p33, p18， p13和p23）在决定CTV感染的致病性中起重要作用。这些orf是CTV独有的，在Closteroviridae家族的其他成员中并不保守。这篇综述的目的是捕捉已被证明参与CTV疾病诱导的因素的复杂性，并强调最近的工作为这一病理系统提供了新的见解。

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Complex interplay: The interactions between citrus tristeza virus and its host

Citrus tristeza virus (CTV) is one of the largest and most economically important RNA viruses infecting plants. CTV's interactions with various citrus hosts can result in three diseases: quick decline, stem pitting, or seedling yellows. Studying CTV poses several challenges owing to its significant genetic diversity and the highly specific occurrence of disease symptoms when different genotypes infect different citrus hosts. Considerable progress has been made to functionally characterize the virus-host interactions involved in the induction of CTV's three diseases, revealing that the four CTV ORFs (p33, p18, p13 and p23) play significant roles in determining the pathogenicity of CTV infections. These ORFs are unique to CTV and are not conserved among other members of the family Closteroviridae. This minireview aims to capture the complexity of the factors that have been shown to be involved in CTV disease induction and highlights recent work that provides novel insights into this pathosystem.

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来源期刊

Virology 医学-病毒学

CiteScore

6.00

自引率

0.00%

发文量

157

审稿时长

50 days

期刊介绍： Launched in 1955, Virology is a broad and inclusive journal that welcomes submissions on all aspects of virology including plant, animal, microbial and human viruses. The journal publishes basic research as well as pre-clinical and clinical studies of vaccines, anti-viral drugs and their development, anti-viral therapies, and computational studies of virus infections. Any submission that is of broad interest to the community of virologists/vaccinologists and reporting scientifically accurate and valuable research will be considered for publication, including negative findings and multidisciplinary work.Virology is open to reviews, research manuscripts, short communication, registered reports as well as follow-up manuscripts.