氯e6衍生物介导的光动力疗法与强力霉素治疗中重度酒渣鼻：一项前瞻性、随机、对照研究。

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-02-01 DOI:10.1016/j.pdpdt.2025.104474

Yun Wu , Qing Fan , Xiaojing Liu , Yajing Cao , Jin Yang , Yu Yan , Hui Tao , Fuhe Zhang , Linglin Zhang , Peiru Wang , Xiuli Wang

{"title":"氯e6衍生物介导的光动力疗法与强力霉素治疗中重度酒渣鼻：一项前瞻性、随机、对照研究。","authors":"Yun Wu , Qing Fan , Xiaojing Liu , Yajing Cao , Jin Yang , Yu Yan , Hui Tao , Fuhe Zhang , Linglin Zhang , Peiru Wang , Xiuli Wang","doi":"10.1016/j.pdpdt.2025.104474","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Photodynamic therapy (PDT) is beneficial for managing rosacea, and chlorin e6 derivative-mediated photodynamic therapy (STBF-PDT) has demonstrated efficacy in reducing acne lesions with mild adverse reactions.</div></div><div><h3>Objectives</h3><div>This study aimed to assess the effectiveness and safety of STBF-PDT for the treatment of moderate-to-severe rosacea.</div></div><div><h3>Methods</h3><div>In this prospective, randomised, evaluator-blind controlled study, patients with moderate-to-severe rosacea were assigned to receive up to six STBF-PDT sessions or 100 mg of doxycycline daily for eight weeks, followed by a 24-week follow-up.</div></div><div><h3>Results</h3><div>A total of 76 patients were enrolled (38 assigned to STBF-PDT and 38 to oral doxycycline) with 69 (36 in the STBF-PDT group and 33 in the doxycycline group) completing the study. At the end of treatment, the median reduction in lesion count was 82.3 % in the STBF-PDT group and 81.8 % in the doxycycline group, indicating no significant difference between the groups. The STBF-PDT group exhibited a lower relapse rate and a significantly higher reduction in <em>Demodex</em> mites. Clinician's Erythema Assessment success (CEA), sensations of burning and pruritus, telangiectasia, and Rosacea-related Quality of Life (RosaQoL) scores were comparable between groups. No severe adverse reactions were observed.</div></div><div><h3>Conclusions</h3><div>STBF-PDT is a promising treatment option for mild-to-moderate rosacea with mild adverse reactions.</div></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"51 ","pages":"Article 104474"},"PeriodicalIF":3.1000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Chlorin e6 derivative-mediated photodynamic therapy versus doxycycline for moderate-to-severe rosacea: A prospective, randomized, controlled study\",\"authors\":\"Yun Wu , Qing Fan , Xiaojing Liu , Yajing Cao , Jin Yang , Yu Yan , Hui Tao , Fuhe Zhang , Linglin Zhang , Peiru Wang , Xiuli Wang\",\"doi\":\"10.1016/j.pdpdt.2025.104474\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Photodynamic therapy (PDT) is beneficial for managing rosacea, and chlorin e6 derivative-mediated photodynamic therapy (STBF-PDT) has demonstrated efficacy in reducing acne lesions with mild adverse reactions.</div></div><div><h3>Objectives</h3><div>This study aimed to assess the effectiveness and safety of STBF-PDT for the treatment of moderate-to-severe rosacea.</div></div><div><h3>Methods</h3><div>In this prospective, randomised, evaluator-blind controlled study, patients with moderate-to-severe rosacea were assigned to receive up to six STBF-PDT sessions or 100 mg of doxycycline daily for eight weeks, followed by a 24-week follow-up.</div></div><div><h3>Results</h3><div>A total of 76 patients were enrolled (38 assigned to STBF-PDT and 38 to oral doxycycline) with 69 (36 in the STBF-PDT group and 33 in the doxycycline group) completing the study. At the end of treatment, the median reduction in lesion count was 82.3 % in the STBF-PDT group and 81.8 % in the doxycycline group, indicating no significant difference between the groups. The STBF-PDT group exhibited a lower relapse rate and a significantly higher reduction in <em>Demodex</em> mites. Clinician's Erythema Assessment success (CEA), sensations of burning and pruritus, telangiectasia, and Rosacea-related Quality of Life (RosaQoL) scores were comparable between groups. No severe adverse reactions were observed.</div></div><div><h3>Conclusions</h3><div>STBF-PDT is a promising treatment option for mild-to-moderate rosacea with mild adverse reactions.</div></div>\",\"PeriodicalId\":20141,\"journal\":{\"name\":\"Photodiagnosis and Photodynamic Therapy\",\"volume\":\"51 \",\"pages\":\"Article 104474\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Photodiagnosis and Photodynamic Therapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1572100025000043\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Photodiagnosis and Photodynamic Therapy","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1572100025000043","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

背景：光动力疗法（PDT）有利于治疗酒渣鼻，氯e6衍生物介导的光动力疗法（STBF-PDT）已被证明可以减少痤疮病变，且不良反应轻微。目的：本研究旨在评估STBF-PDT治疗中重度酒渣鼻的有效性和安全性。结果：共有76例患者入组（38例分配到STBF-PDT组，38例分配到口服强力霉素组），其中69例（STBF-PDT组36例，强力霉素组33例）完成了研究。治疗结束时，STBF-PDT组和强力霉素组的中位病变计数减少率分别为82.3%和81.8%，两组间无显著差异。STBF-PDT组表现出较低的复发率和显著较高的蠕形螨的减少。临床医生的红斑评估成功（CEA）、灼烧和瘙痒的感觉、毛细血管扩张和红斑痤疮相关的生活质量（RosaQoL）评分在两组之间具有可比性。未见严重不良反应。结论：STBF-PDT治疗轻至中度酒渣鼻是一种有希望的治疗选择，不良反应轻微。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

A Chlorin e6 derivative-mediated photodynamic therapy versus doxycycline for moderate-to-severe rosacea: A prospective, randomized, controlled study

Background

Photodynamic therapy (PDT) is beneficial for managing rosacea, and chlorin e6 derivative-mediated photodynamic therapy (STBF-PDT) has demonstrated efficacy in reducing acne lesions with mild adverse reactions.

Objectives

This study aimed to assess the effectiveness and safety of STBF-PDT for the treatment of moderate-to-severe rosacea.

Methods

In this prospective, randomised, evaluator-blind controlled study, patients with moderate-to-severe rosacea were assigned to receive up to six STBF-PDT sessions or 100 mg of doxycycline daily for eight weeks, followed by a 24-week follow-up.

Results

A total of 76 patients were enrolled (38 assigned to STBF-PDT and 38 to oral doxycycline) with 69 (36 in the STBF-PDT group and 33 in the doxycycline group) completing the study. At the end of treatment, the median reduction in lesion count was 82.3 % in the STBF-PDT group and 81.8 % in the doxycycline group, indicating no significant difference between the groups. The STBF-PDT group exhibited a lower relapse rate and a significantly higher reduction in Demodex mites. Clinician's Erythema Assessment success (CEA), sensations of burning and pruritus, telangiectasia, and Rosacea-related Quality of Life (RosaQoL) scores were comparable between groups. No severe adverse reactions were observed.

Conclusions

STBF-PDT is a promising treatment option for mild-to-moderate rosacea with mild adverse reactions.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.