George Fotakopoulos, Vasiliki Epameinondas Georgakopoulou, Demetrios A Spandidos, Efthalia Angelopoulou, Apostolos-Alkiviadis Menis, Nikolaos Trakas, George Alexiou, Spyridon Voulgaris
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引用次数: 0
摘要
本研究探讨了Simpson分级系统、mb -1免疫组织化学标志物、脑膜瘤的位置和分级在复发风险中的作用。2008年1月至2018年1月,本研究回顾性评估了所有接受开颅手术切除组织病理学证实的脑膜瘤的患者。排除了术前有神经纤维瘤病、听神经瘤和放疗的患者。应用排除标准后,103例患者纳入研究。平均随访67.3±33个月,肿瘤复发12例(11.6%)。脑膜瘤复发与年龄、性别或肿瘤部位无明显关联。比较Simpson I级、II级、III级、IV级和Simpson V级之间的复发风险,差异有统计学意义。当比较WHO一级和二级脑膜瘤与三级脑膜瘤时,差异是显著的。mb -1 LI >3%与复发风险呈显著相关趋势。总的来说,本研究表明辛普森评分与复发风险相关。mb -1指数为bb0 3%的肿瘤患者也可能有复发的风险。值得注意的是,本研究提出,在复发的情况下,这更有可能发生在手术干预后的5.5年。
Prognostic factors for first recurrence following meningioma surgery.
The present study investigated the role of the Simpson grade system, MIB-1 immunohistochemical marker, meningioma location and grade in the risk of recurrence. Between January, 2008 and January, 2018, the present study retrospectively evaluated all patients undergoing craniotomy for the resection of a histopathologically confirmed meningioma. Patients with neurofibromatosis, acoustic neurinomas and radiation treatment prior to surgery were excluded. After applying the exclusion criteria, 103 patients were included in the study. Following a mean follow-up period of 67.3±33 months, there were 12 cases (11.6%) of tumor recurrence. No significant association between meningioma recurrence and age, sex, or tumor location was found. When comparing the risk of recurrence between Simpson grades I, II, III and IV excisions, and between Simpson grade V, the difference was statistically significant. When comparing WHO grade I and II meningioma vs. grade III, the difference was significant. MIB-1 LI >3% exhibited a trend towards a significant association with the risk of recurrence. On the whole, the present study demonstrates that the Simpson grade is associated with the risk of recurrence. Patients with tumors with an MIB-1 index >3% may also be at a risk of recurrence. Notably, the present study proposed that in the case of recurrence, this is more likely to occur in an interval of 5.5 years following surgical intervention.