Tarik Safak, Nevzat Saat, Oznur Yilmaz-Koc, Mert Turanli, Aslıhan Ayalp-Erkan, Ali Risvanli
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High-Sensitive Cardiac Troponin I and Th1/Th2 Polarization in Queens With Pyometra.
Objectives: To determine T helper (Th)1 and Th2 cytokine polarization, as well as high-sensitive cardiac troponin I (hs-cTnI) levels, in cats with pyometra.
Methods: We used 40 queens in the study. A total of 20 out of these 40 queens were diagnosed with the pyometra group (PYO) and the other 20 made up the healthy group (control; CTR). We measured concentrations of hs-cTnI, aspartate aminotransferase (AST), creatine kinase (CK) and l-lactate in queens from both groups. Additionally, we measured cytokine concentrations in all queens.
Results: The hs-cTnI concentration in the PYO group (26.95 ± 5.08 ng/L) was significantly higher than that of the CTR group (7.00 ± 0.82 ng/L) (p < 0.000). Furthermore, the PYO group had a higher CK concentration (344.50 ± 39.63 U/L) than the CTR group (191.00 ± 15.44 U/L) (p = 0.002). The PYO group also demonstrated higher concentrations of TNF-α (9.77 ± 0.81 ng/mL), IFN-γ (25.37 ± 2.09 ng/mL), IL-2 (4.37 ± 0.39 ng/mL), IL-4 (245.64 ± 15.83 pg/mL), IL-5 (63.13 ± 1.65 pg/mL) and IL-10 (123.58 ± 4.30 ng/mL) compared to the CTR group (p < 0.000).
Conclusions: Overall, it is suggested that changes in cytokine concentrations increase in queens with pyometra, potentially causing harm to the heart muscle. It is crucial to consider that the heart muscle may also be affected in queens with pyometra during the treatment process.
期刊介绍：
Veterinary Medicine and Science is the peer-reviewed journal for rapid dissemination of research in all areas of veterinary medicine and science. The journal aims to serve the research community by providing a vehicle for authors wishing to publish interesting and high quality work in both fundamental and clinical veterinary medicine and science.
Veterinary Medicine and Science publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.
We aim to be a truly global forum for high-quality research in veterinary medicine and science, and believe that the best research should be published and made widely accessible as quickly as possible. Veterinary Medicine and Science publishes papers submitted directly to the journal and those referred from a select group of prestigious journals published by Wiley-Blackwell.
Veterinary Medicine and Science is a Wiley Open Access journal, one of a new series of peer-reviewed titles publishing quality research with speed and efficiency. For further information visit the Wiley Open Access website.
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