Makoto Kawai, S M Hadi Hosseini, Casey Buck, Rosy Karna, Kai Ayinde Parker-Fong, Pahnwat Tonya Taweesedt
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引用次数: 0
摘要
背景：间歇性缺氧是睡眠呼吸障碍（SDB）的结果，可能会增加认知能力下降的风险。然而，SDB与认知之间的关系仍然是高度可变的。方法：招募52名居住在社区的健康老年人（28名女性）。所有参与者都接受了神经精神评估、同步动态多导睡眠图（PSG）和近红外光谱（NIRS）记录。我们量化了SDB事件中氧- hb和SpO2信号之间的平均一致性，以确定它是否可以预测健康老年人的认知结果，在健康老年人中，较高的一致性表明对全身缺氧的保护能力降低。结果：oxy-Hb与SpO2的平均（SD）相干度为0.16（0.07）。线性回归分析显示，平均连贯性与较差的Stroop颜色单词测试成绩之间存在显著相关（t=-0.304, p = 0.004）。相比之下，氧- hb还原单独和常规SDB参数没有显示出与认知的显著关联。结论：这是第一个证明SDB中脑系统氧合一致性的新参数与老年人认知之间存在关联的报告。在SDB期间，较高的皮质氧- hb和全身SpO2一致性率可能反映了对全身缺氧的代偿机制的丧失，并可能有助于对认知能力下降风险较高的老年人进行分层。
The impact of brain-systemic oxygenation coupling in sleep-disordered breathing on cognitive function in elderly.
Background: Intermittent hypoxia, a consequence of sleep-disordered breathing (SDB), may contribute to an increased risk of cognitive decline. However, the association between SDB and cognition remains highly variable.
Methods: Fifty-two community-dwelling healthy older adults (28 women) were recruited. All participants underwent neuropsychiatric evaluations, simultaneous ambulatory polysomnography (PSG), and near-infrared spectroscopy (NIRS) recordings. We quantified the average coherence between oxy-Hb and SpO2 signals during SDB events to determine whether it could predict cognitive outcomes in healthy older adults, where higher coherence indicates reduced protection against systemic hypoxia.
Results: The mean (SD) coherence of oxy-Hb and SpO2 was 0.16 (0.07). Linear regression analysis showed a significant association between mean coherence and worse Stroop Color Word Test scores (t=-0.304, p = .004). In contrast, oxy-Hb reduction alone and conventional SDB parameters did not show a significant association with cognition.
Conclusion: This is the first report to demonstrate an association between a novel parameter of brain-systemic oxygenation coherence in SDB and cognition in older adults. A higher coherence rate of cortical oxy-Hb and systemic SpO2 during SDB may reflect a loss of compensatory mechanisms against systemic hypoxia and could help stratify older adults with a higher risk for cognitive decline.
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