雷公藤多苷诱导生殖毒性的机制及解毒策略。

IF 3.3 4区医学 Q2 REPRODUCTIVE BIOLOGY

Reproductive toxicology Pub Date : 2025-01-06 DOI:10.1016/j.reprotox.2025.108830

Zechen Niu , Huanhuan Zhang , Chunzhou Cai , Ting Yang , Tian Ma , Dingqiao Xu , Dongxiao Cui , Yuping Tang

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引用次数: 0

摘要

雷公藤多苷（TG）是一种广泛用于治疗类风湿性关节炎（RA）、肾病综合征和糖尿病肾病的制剂。虽然临床疗效明确，但对生殖系统的不良反应限制了其广泛应用。采取措施减轻其生殖毒性，扩大其临床应用具有重要意义。tg诱导生殖毒性的机制涉及氧化应激、炎症、细胞凋亡和代谢失衡等，对雌雄生殖器官产生不良影响。为了减轻这些影响，包括将TG与其他药物结合在内的解毒策略已被证明可以抵消其毒性。本文综述将为TG诱导生殖毒性的研究提供信息，并为开发新的策略来减轻TG的生殖副作用提供见解。

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The mechanisms of tripterygium glycosides-induced reproductive toxicity and detoxification strategies

Tripterygium glycosides (TG) is a widely used preparation in the treatment of rheumatoid arthritis (RA), nephrotic syndrome and diabetic nephropathy. Although the clinical efficacy is definite, the side-effects on reproductive system limit its wide application. It is of great significance to take measures to alleviate its reproductive toxicity and expand its clinical use. The mechanism of TG-induced reproductive toxicity involves oxidative stress, inflammation, apoptosis, and metabolism imbalance, which lead to adverse effects on male and female reproductive organs. To mitigate these effects, detoxification strategies including combining TG with other agents have been proved to counteract its toxicity. This review will provide information for the studies of TG-induced reproductive toxicity, and also provide insights for developing novel strategies to alleviate the reproductive side effects of TG.

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来源期刊

Reproductive toxicology 生物-毒理学

CiteScore

6.50

自引率

3.00%

发文量

131

审稿时长

45 days

期刊介绍： Drawing from a large number of disciplines, Reproductive Toxicology publishes timely, original research on the influence of chemical and physical agents on reproduction. Written by and for obstetricians, pediatricians, embryologists, teratologists, geneticists, toxicologists, andrologists, and others interested in detecting potential reproductive hazards, the journal is a forum for communication among researchers and practitioners. Articles focus on the application of in vitro, animal and clinical research to the practice of clinical medicine. All aspects of reproduction are within the scope of Reproductive Toxicology, including the formation and maturation of male and female gametes, sexual function, the events surrounding the fusion of gametes and the development of the fertilized ovum, nourishment and transport of the conceptus within the genital tract, implantation, embryogenesis, intrauterine growth, placentation and placental function, parturition, lactation and neonatal survival. Adverse reproductive effects in males will be considered as significant as adverse effects occurring in females. To provide a balanced presentation of approaches, equal emphasis will be given to clinical and animal or in vitro work. Typical end points that will be studied by contributors include infertility, sexual dysfunction, spontaneous abortion, malformations, abnormal histogenesis, stillbirth, intrauterine growth retardation, prematurity, behavioral abnormalities, and perinatal mortality.