皮肤完整性再生的生物工程策略：文献综述。

IF 3.4 3区环境科学与生态学 Q3 CELL & TISSUE ENGINEERING

Regenerative Therapy Pub Date : 2024-12-15 DOI:10.1016/j.reth.2024.12.006

Makoto Shiraishi , Yoshihiro Sowa , Ataru Sunaga , Kenta Yamamoto , Mutsumi Okazaki

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引用次数: 0

摘要

目的：皮肤是一个包含多种干细胞群的复杂器官。目前的方法无法愈合的皮肤缺陷有时是不充分的，许多尝试已作出再生皮肤的完整性。本文综述的目的是弥合皮肤完整性再生的基础研究和临床应用之间的差距。方法：结合关键词“皮肤完整性”、“组织工程皮肤”、“生物工程皮肤”和“皮肤再生”，在PubMed中进行文献检索。从1968年到2023年发表的文章报道了体内和体外皮肤再生实验的证据。结果：干细胞可以分化为正常皮肤细胞，包括角质形成细胞，是皮肤类器官的重要来源，对研究皮肤生物学有重要意义；新兴的直接重编程方法具有从受伤皮肤表面再生皮肤的巨大潜力。结论：近年来在皮肤再生方面的研究进展将促进皮肤生物学基础和临床研究的进一步发展。

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Bioengineering strategies for regeneration of skin integrity: A literature review

Objective

The skin is a complex organ that includes various stem cell populations. Current approaches for non-healing skin defects are sometimes inadequate and many attempts have been made to regenerate skin integrity. The aim of this review is to bridge the gap between basic research and clinical application of skin integrity regeneration.

Methods

A literature search was carried out in PubMed using combinations of the keywords “skin integrity”, “tissue-engineered skin”, “bioengineered skin”, and “skin regeneration”. Articles published from 1968 to 2023 reporting evidence from in vivo and in vitro skin regeneration experiments were included.

Results

These articles showed that stem cells can be differentiated into normal skin cells, including keratinocytes, and are a significant source of skin organoids, which are useful for investigating skin biology; and that emerging direct reprogramming methods have great potential to regenerate skin from the wounded skin surface.

Conclusion

Recent advances in skin regeneration will facilitate further advancement of both basic and clinical research in skin biology.

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来源期刊

Regenerative Therapy Engineering-Biomedical Engineering

CiteScore

6.00

自引率

2.30%

发文量

106

审稿时长

49 days

期刊介绍： Regenerative Therapy is the official peer-reviewed online journal of the Japanese Society for Regenerative Medicine. Regenerative Therapy is a multidisciplinary journal that publishes original articles and reviews of basic research, clinical translation, industrial development, and regulatory issues focusing on stem cell biology, tissue engineering, and regenerative medicine.