精神分裂症患者持续性听觉言语幻觉的多层网络不稳定性。

IF 4.2 2区医学 Q1 PSYCHIATRY

Psychiatry Research Pub Date : 2025-02-01 DOI:10.1016/j.psychres.2024.116351

Jinguang Li , Jingqi He , Honghong Ren , Zongchang Li , Xiaoqian Ma , Liu Yuan , Lijun Ouyang , Chunwang Li , Xiaogang Chen , Ying He , Jinsong Tang

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引用次数: 0

摘要

背景：精神分裂症（SCZ）患者的言语幻听（AVHs）与大脑网络异常有关。静息状态fMRI研究通常假设扫描期间的网络稳定，但与avh相关的动态变化尚未得到很好的理解。方法：我们分析了60例伴有持续性AVHs （p-AVHs）的SCZ患者、39例无AVHs （n-AVHs）的SCZ患者和59例健康对照（hc）的静息状态fMRI数据，这些数据在人口统计学上是匹配的。利用图论构造了一个时变的脑网络模块结构，重点研究了多层模块结构。在全局、子网和节点水平上比较各组之间的网络切换率，并与AVH严重程度相关。结果：与hc组相比，SCZ组皮质下网络的转换率更高。两组患者均发现两个丘脑节点的开关增加。与HC和n-AVH组相比，p-AVH组在默认模式网络（DMN）和两个额上回节点的切换率较低。在p-AVH组，DMN转换率与AVH严重程度呈负相关。结论：脑网络的动态变化，特别是DMN和额叶区转换率的降低，可能是SCZ中AVHs发生和持续的原因。

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Multilayer network instability underlying persistent auditory verbal hallucinations in schizophrenia

Background

Auditory verbal hallucinations (AVHs) in schizophrenia (SCZ) are linked to brain network abnormalities. Resting-state fMRI studies often assume stable networks during scans, yet dynamic changes related to AVHs are not well understood.

Methods

We analyzed resting-state fMRI data from 60 SCZ patients with persistent AVHs (p-AVHs), 39 SCZ patients without AVHs (n-AVHs), and 59 healthy controls (HCs), matched for demographics. Using graph theory, we constructed a time-varying modular structure of brain networks, focusing on multilayer modularity. Network switching rates at global, subnetwork, and nodal levels were compared across groups and related to AVH severity.

Results

SCZ groups had higher switching rates in the subcortical network compared to HCs. Increased switching was found in two thalamic nodes for both patient groups. The p-AVH group showed lower switching rates in the default mode network (DMN) and two superior frontal gyrus nodes compared to HC and n-AVH groups. DMN switching rates negatively correlated with AVH severity in the p-AVH group.

Conclusions

Dynamic changes in brain networks, especially lower DMN and frontal region switching rates, may contribute to the development and persistence of AVHs in SCZ.

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来源期刊

Psychiatry Research 医学-精神病学

CiteScore

17.40

自引率

1.80%

发文量

527

审稿时长

57 days

期刊介绍： Psychiatry Research offers swift publication of comprehensive research reports and reviews within the field of psychiatry. The scope of the journal encompasses: Biochemical, physiological, neuroanatomic, genetic, neurocognitive, and psychosocial determinants of psychiatric disorders. Diagnostic assessments of psychiatric disorders. Evaluations that pursue hypotheses about the cause or causes of psychiatric diseases. Evaluations of pharmacologic and non-pharmacologic psychiatric treatments. Basic neuroscience studies related to animal or neurochemical models for psychiatric disorders. Methodological advances, such as instrumentation, clinical scales, and assays directly applicable to psychiatric research.