胎儿胎盘生长与母亲体力活动量和静坐时间之间的性别特异性关联：来自昆士兰家庭队列研究的发现。

IF 3 2区医学 Q2 DEVELOPMENTAL BIOLOGY

Placenta Pub Date : 2025-02-01 DOI:10.1016/j.placenta.2024.12.027

Jade M. Kubler , Kassia S. Beetham , Sarah E. Steane , Olivia J. Holland , Danielle J. Borg , Kym M. Rae , Sailesh Kumar , Vicki L. Clifton

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引用次数: 0

摘要

产前体育活动（PA）与胎盘生长和功能的有益变化有关；然而，久坐的影响还不太清楚。本研究的目的是调查胎儿胎盘生长是否随母体活动而改变，以及这些关联是否以性别特异性的方式不同。方法：本研究包括参加昆士兰家庭队列研究的妇女，她们在妊娠24或36周时自我报告PA和坐着时间。分娩时胎盘生长因子和胎儿胎盘生长参数通过胎心容积、坐位时间以及胎儿性别进行分析。结果：怀孕中期坐着时间过长的女性胎儿胎盘PlGF （p = 0.031）和FLT1 (p = 0.032) mRNA表达较高，分娩时胎盘大小无差异。对于男性来说，妊娠中期坐着时间过长与胎盘重量（p = 0.001）和胎盘表面积（p = 0.012）降低以及出生体重与胎盘重量（BWPW）比（p = 0.042）升高有关，而胎盘生长因子没有变化。妊娠中期中等体积PA与男性胎盘中较低的VEGFA mRNA表达（p = 0.005）和女性新生儿较高的腹围（p = 0.042）相关，胎盘重量或出生体重在两性中没有总体差异。结论：本研究结果表明，妊娠中期可能是与母体活动有关的胎儿-胎盘生长规划的重要时间点。我们的研究结果强调了怀孕期间减少坐着时间的独立好处，尤其是对怀男性胎儿的女性。

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Sex-specific associations between feto-placental growth and maternal physical activity volume and sitting time: Findings from the Queensland Family Cohort study

Introduction

Antenatal physical activity (PA) is associated with beneficial changes in placental growth and function; however, the effect of excessive sitting time is less clear. The aim of this study was to investigate whether feto-placental growth changes with maternal activity, and whether these associations differ in a sex-specific manner.

Methods

This study included women enrolled in the Queensland Family Cohort study who self-reported PA and sitting time at 24 or 36 weeks of gestation. Placental growth factors and feto-placental growth parameters at delivery were analysed by PA volume and sitting time, as well as by fetal sex.

Results

Women who reported excessive sitting time during mid-pregnancy and had a female fetus showed higher placental PlGF (p = 0.031) and FLT1 (p = 0.032) mRNA expression with no difference in placental size at delivery. For the male, excessive sitting time during mid-pregnancy was associated with a lower placental weight (p = 0.001) and placental surface area (p = 0.012) and a higher birthweight to placental weight (BWPW) ratio (p = 0.042), with no change in placental growth factors. Moderate volume PA during mid-pregnancy was associated with lower VEGFA mRNA expression in the male placenta (p = 0.005) and a higher abdominal circumference in the female neonate (p = 0.042), with no overall difference in placental weight or birthweight for either sex.

Conclusions

The results of this study suggest that mid-pregnancy may be an important timepoint for programming of feto-placental growth in relation to maternal activity. Our findings highlight the independent benefits of reducing sitting time during pregnancy, particularly for women carrying male fetuses.

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来源期刊

Placenta 医学-发育生物学

CiteScore

6.30

自引率

10.50%

发文量

391

审稿时长

78 days

期刊介绍： Placenta publishes high-quality original articles and invited topical reviews on all aspects of human and animal placentation, and the interactions between the mother, the placenta and fetal development. Topics covered include evolution, development, genetics and epigenetics, stem cells, metabolism, transport, immunology, pathology, pharmacology, cell and molecular biology, and developmental programming. The Editors welcome studies on implantation and the endometrium, comparative placentation, the uterine and umbilical circulations, the relationship between fetal and placental development, clinical aspects of altered placental development or function, the placental membranes, the influence of paternal factors on placental development or function, and the assessment of biomarkers of placental disorders.