放疗后鼻咽坏死伴肉芽团块：来自多中心研究的见解。

IF 4 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral oncology Pub Date : 2025-02-01 Epub Date: 2025-01-08 DOI:10.1016/j.oraloncology.2024.107170

Zheng-Kai Feng, Wen-Bin Wu, Rui-Chao Zou, Jian-Zhong Zhang, Hai-Qiong Huang, Xin-Rui Zhang, Ying-Qi Wang, Si-Yuan Chen, Xi Ding, Rui You, You-Ping Liu, Ming-Yuan Chen

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引用次数: 0

摘要

背景：放疗后鼻咽坏死伴肉芽团（PRNN- gm）是放疗后鼻咽坏死（PRNN）的一种罕见亚型。它的特点是形成孤立的肉芽肿组织肿块或肿块合并PRNN。然而，PRNN-GM的临床特征与生存结果之间的关系尚不清楚。方法：本回顾性研究系统评估了2010年1月至2024年5月在三家医疗中心治疗的33例病理诊断的PRNN-GM患者。分析患者的临床特点、内镜及影像学特征、治疗方法及生存结局。结果：33例患者中，男性27例，女性6例，平均年龄52 岁（±10.9 岁）。5例患者颈动脉暴露。手术治疗19例，保守治疗14例。内颈动脉暴露（OR = 6.863,95 % CI: 1.196-39.385）和手术治疗（OR = 0.130,95 % CI: 0.026-0.659）被确定为影响生存结局的独立预后因素(P 结论：内颈动脉暴露且未进行手术治疗的PRNN-GM患者预后较差。

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Postradiotherapy nasopharyngeal necrosis with granulation mass: Insights from a multicentre study.

Background: Postradiotherapy nasopharyngeal necrosis with granulation mass (PRNN-GM) is a rare subtype of postradiotherapy nasopharyngeal necrosis (PRNN). It is characterized by the formation of isolated granulomatous tissue masses or masses combined with PRNN. However, the relationship between clinical features and survival outcomes in PRNN-GM remains unclear.

Methods: This retrospective study systematically evaluated 33 pathologically diagnosed PRNN-GM patients treated at three medical centres from January 2010 to May 2024. The clinical features, endoscopic and imaging characteristics, treatment methods, and survival outcomes of the patients were analysed.

Results: Among the 33 patients, 27 were male and 6 were female, with a mean age of 52 years (±10.9 years). Internal carotid artery exposure was observed in 5 patients. Nineteen patients underwent surgical treatment, whereas 14 received conservative management. Internal carotid artery exposure (OR = 6.863, 95 % CI: 1.196-39.385) and surgical treatment (OR = 0.130, 95 % CI: 0.026-0.659) were identified as independent prognostic factors influencing survival outcomes (P < 0.05).

Conclusions: Patients with PRNN-GM who have internal carotid artery exposure and do not undergo surgical treatment tend to have a poorer prognosis.

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来源期刊

Oral oncology 医学-牙科与口腔外科

CiteScore

8.70

自引率

10.40%

发文量

505

审稿时长

20 days

期刊介绍： Oral Oncology is an international interdisciplinary journal which publishes high quality original research, clinical trials and review articles, editorials, and commentaries relating to the etiopathogenesis, epidemiology, prevention, clinical features, diagnosis, treatment and management of patients with neoplasms in the head and neck. Oral Oncology is of interest to head and neck surgeons, radiation and medical oncologists, maxillo-facial surgeons, oto-rhino-laryngologists, plastic surgeons, pathologists, scientists, oral medical specialists, special care dentists, dental care professionals, general dental practitioners, public health physicians, palliative care physicians, nurses, radiologists, radiographers, dieticians, occupational therapists, speech and language therapists, nutritionists, clinical and health psychologists and counselors, professionals in end of life care, as well as others interested in these fields.