基于7.0T MRI结构和连通性分析的健康人基底神经节、丘脑和供血动脉侧化研究

IF 4.7 2区医学 Q1 NEUROIMAGING

NeuroImage Pub Date : 2025-02-01 DOI:10.1016/j.neuroimage.2025.121007

Hongqin Liang , Yawei Gu , Xiaoqi Yi , Li Kong , Jian Wang , Fajin Lv

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引用次数: 0

摘要

人类大脑皮层以其半球特化而闻名，它支撑着各种功能和活动。然而，是否类似的侧化存在于深部灰质核，如基底神经节（BG）和丘脑，以及它们的相关动脉，包括皮质纹状体动脉（LSAs），目前还不清楚。为了探讨这一点，我们分析了40名健康年轻人的7T MRI扫描图像。我们分离了LSAs并分析了它们的形态特征。此外，我们基于脑组图谱将双侧BG和丘脑划分为28个亚区，并使用基于单受试者体素的形态测量（VBM）分析计算了它们的体积。我们还从这28个子区域的扩散张量成像（DTI）中获得了四个参数。采用配对t检验对所有测量值进行双边比较。基于连接纤维的数量和子区域之间的分数各向异性，构建了连接网络矩阵。结果表明，在右撇子优势群体中，我们观察到左半球LSAs的总数和长度超过右半球。在28个亚区中，有几个显示左侧体积优势，包括腹侧尾状核、苍白球、腹内侧壳核、内侧前额丘脑、枕侧丘脑和尾侧颞丘脑。相反，伏隔核、尾状背核、壳核背外侧、运动前丘脑、感觉丘脑、顶叶后丘脑和外侧额前丘脑的体积向右占优势。除腹侧内侧壳核（vmPu）外，所有其他亚核均显示至少三个DTI测量值，且左右差异。子区域之间的连通性在双侧半球显示出明显的模式，以左为主。总的来说，这些发现增强了我们对皮层下结构侧化的理解。

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Lateralization study of the basal ganglia, thalamus and supplying arteries in healthy individuals based on structure and connectivity analysis using 7.0T MRI

The human cerebral cortex is known for its hemispheric specialization, which underpins a variety of functions and activities. However, it is not well understood if similar lateralization exists within the deep gray matter nuclei, such as the basal ganglia (BG) and thalamus, and their associated arteries, including the lenticulostriate arteries (LSAs). To explore this, we analyzed images from 7T MRI scans of 40 healthy young individuals. We isolated the LSAs and analyzed their morphological characteristics. Additionally, we segmented the bilateral BG and thalami into 28 subregions based on the Brainnetome atlas and calculated their volumes using single-subject voxel-based morphometry (VBM) analysis. We also obtained four parameters from Diffusion Tensor Imaging (DTI) within these 28 subregions. Bilateral comparisons were conducted using paired t-tests for all measurements. Connectivity-network matrices, based on the number of connecting fibers and fractional anisotropy between subregions, were constructed. The results showed that in the right-handed dominant population, we observed that the total number and length of LSAs in the left hemisphere exceeded those in the right. Among the 28 subregions, several showed leftward volume dominance, including the ventral caudate, globus pallidus, ventromedial putamen, medial pre-frontal thalamus, occipital thalamus, and caudal temporal thalamus. In contrast, the nucleus accumbens, dorsal caudate, dorsolateral putamen, pre-motor thalamus, sensory thalamus, posterior parietal thalamus, and lateral pre-frontal thalamus showed rightward volume dominance. Except for the ventral medial putamen (vmPu), all other subnuclei displayed at least three DTI measures with left-right differences. The connectivity between subregions revealed distinct patterns in the bilateral hemispheres, with a leftward dominance. Collectively, these findings enhance our understanding of lateralization within subcortical structures.

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来源期刊

NeuroImage 医学-核医学

CiteScore

11.30

自引率

10.50%

发文量

809

审稿时长

63 days

期刊介绍： NeuroImage, a Journal of Brain Function provides a vehicle for communicating important advances in acquiring, analyzing, and modelling neuroimaging data and in applying these techniques to the study of structure-function and brain-behavior relationships. Though the emphasis is on the macroscopic level of human brain organization, meso-and microscopic neuroimaging across all species will be considered if informative for understanding the aforementioned relationships.