体质指数对中国人群甲状腺乳头状癌临床病理特征的影响。

IF 1.3 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Li Zhang, Shichen Xu, Xian Cheng, Yun Zhu, Gangming Cai, Jing Wu, Wenjing Gao, Jiandong Bao, Huixin Yu
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引用次数: 0

摘要

背景:以前的研究表明肥胖与甲状腺癌的高风险之间存在关系。然而,高身体质量指数(BMI)与甲状腺乳头状癌(PTC)侵袭性之间的关系存在争议。在这项研究中,我们旨在调查中国人群中BMI过高对PTC组织病理侵袭性的影响。方法:纳入2015年1月至2020年9月在江源医院进行BRAF突变检测的4369例PTC患者。采用Logistic回归分析评估BMI与PTC临床病理特征以及肿瘤BRAF突变状态之间的关系。结果:4369例PTC患者中,平均BMI为24.06±3.49 kg/m2,其中3528例(80.8%)患者检测到BRAFV600E突变。初始手术时BMI≥24.0与肿瘤多灶性和双侧性相关,但与肿瘤分期晚期、甲状腺外扩张(ETE)、阳性淋巴结比例>.3、远处转移或BRAFV600E突变无关。结论:我们目前的研究表明,与BMI正常的患者相比,超重和肥胖患者有更大的多灶性和双侧PTC的风险。较高的BMI与较晚期的肿瘤-淋巴结-转移阶段或BRAFV600E突变状态之间没有显著关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Influence of Body Mass Index on the Clinicopathological Features of Papillary Thyroid Carcinoma in a Chinese Population.

Background: Previous studies suggested a relationship between obesity and a high risk of thyroid cancer. However, the association between high body mass index (BMI) and the aggressiveness of papillary thyroid carcinoma (PTC) is controversial. In this study, we aimed to investigate the impact of excess BMI on histopathologic aggressiveness of PTC in a Chinese population. Methods: Between January 2015 and September 2020, 4369 PTC patients who were tested for BRAF mutation at Jiangyuan Hospital were enrolled. Logistic regression analyses were used to evaluate the associations between BMI and clinicopathological features of PTC as well as tumor BRAF mutational status. Results: Of 4369 PTC patients, the mean BMI was 24.06 ± 3.49 kg/m2, and BRAFV600E mutations were detected in 3528 (80.8%) patients. BMI ≥24.0 at initial surgery was associated with tumor multifocality and bilaterality, but not with advanced tumor stage, extrathyroidal extension (ETE), ratio of positive lymph nodes >0.3, distant metastasis, or BRAFV600E mutation. Conclusion: Our present study suggested that compared to patients with a normal BMI, overweight and obese patients had a greater risk of multifocality and bilaterality of PTC. No significant associations were observed between higher BMI and the more advanced tumor-node-metastasis stage or BRAFV600E mutational status.

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来源期刊
Metabolic syndrome and related disorders
Metabolic syndrome and related disorders MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
3.40
自引率
0.00%
发文量
74
审稿时长
6-12 weeks
期刊介绍: Metabolic Syndrome and Related Disorders is the only peer-reviewed journal focusing solely on the pathophysiology, recognition, and treatment of this major health condition. The Journal meets the imperative for comprehensive research, data, and commentary on metabolic disorder as a suspected precursor to a wide range of diseases, including type 2 diabetes, cardiovascular disease, stroke, cancer, polycystic ovary syndrome, gout, and asthma. Metabolic Syndrome and Related Disorders coverage includes: -Insulin resistance- Central obesity- Glucose intolerance- Dyslipidemia with elevated triglycerides- Low HDL-cholesterol- Microalbuminuria- Predominance of small dense LDL-cholesterol particles- Hypertension- Endothelial dysfunction- Oxidative stress- Inflammation- Related disorders of polycystic ovarian syndrome, fatty liver disease (NASH), and gout
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