褪黑素对卵巢储备功能减退女性卵泡氧化应激和art预后的影响：一项随机对照试验。

IF 3.8 3区医学 Q1 REPRODUCTIVE BIOLOGY

Journal of Ovarian Research Pub Date : 2025-01-08 DOI:10.1186/s13048-024-01584-0

Sonia Sadeghpour, Morteza Ghasemnejad-Berenji, Farzad Maleki, Tahereh Behroozi-Lak, Robabeh Bahadori, Hojat Ghasemnejad-Berenji

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引用次数: 0

摘要

背景：研究褪黑素对卵巢储备功能减退（DOR）女性卵泡氧化应激和辅助生殖技术（ART）结果的影响。方法：我们将68名接受ART治疗的DOR女性纳入随机对照试验。从她们月经周期的第五天开始，我们每天给她们服用3毫克褪黑素或安慰剂，然后刺激她们的卵巢。我们在取卵过程中获得卵泡液，评估其氧化应激指标，并记录ART结果。结果：褪黑素可显著提高取卵量、受精率和胚胎质量。此外，褪黑素改变氧化应激标志物，特别是还原型谷胱甘肽（rGSH）水平和总抗氧化能力（TAC）。褪黑素组的生化妊娠率显著升高。结论：褪黑素可能通过降低卵泡中的氧化应激来改善卵巢储备不足的女性的卵母细胞质量，并有助于生殖技术。

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The effects of melatonin on follicular oxidative stress and art outcomes in women with diminished ovarian reserve: a randomized controlled trial.

Background: To investigate the impact of Melatonin on follicular oxidative stress and assisted reproductive technology (ART) outcomes in women with diminished ovarian reserve (DOR).

Method: We put 68 women with DOR who were going through ART into a randomized controlled trial. Starting on the fifth day of their menstrual cycle, we gave them either 3 mg of Melatonin or a placebo every day before stimulating their ovaries. We obtained follicular fluid during oocyte retrieval, assessed it for oxidative stress indicators, and documented ART outcomes.

Results: Melatonin administration markedly enhanced the quantity of oocytes retrieved, fertilization rates, and embryo quality. In addition, Melatonin changed markers of oxidative stress, specifically the levels of reduced glutathione (rGSH) and total antioxidant capacity (TAC). The Melatonin group exhibited significantly elevated biochemical pregnancy rates.

Conclusion: Melatonin may improve the quality of oocytes and help with reproductive technology in women with low ovarian reserves, possibly by lowering oxidative stress in the follicles.

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来源期刊

Journal of Ovarian Research REPRODUCTIVE BIOLOGY-

CiteScore

6.20

自引率

2.50%

发文量

125

审稿时长

>12 weeks

期刊介绍： Journal of Ovarian Research is an open access, peer reviewed, online journal that aims to provide a forum for high-quality basic and clinical research on ovarian function, abnormalities, and cancer. The journal focuses on research that provides new insights into ovarian functions as well as prevention and treatment of diseases afflicting the organ. Topical areas include, but are not restricted to: Ovary development, hormone secretion and regulation Follicle growth and ovulation Infertility and Polycystic ovarian syndrome Regulation of pituitary and other biological functions by ovarian hormones Ovarian cancer, its prevention, diagnosis and treatment Drug development and screening Role of stem cells in ovary development and function.