Comparison of single-point insulin sensitivity estimator (SPISE) index and cognitive performance in vitamin B12-deficient young adults: An analytical cross-sectional study.

Background: Vitamin B₁₂ is an essential micronutrient, aids in synthesis of neurotransmitters, and vital for cognitive function. In the current younger population with more of electronic gadgets and scientific world seems to slow down critical thinking and impairs the trick of comprehensive subjective learning. Vitamin B₁₂ deficiency has been linked to insulin-resistant state and future cardiovascular risk.

Aim: This study compared single-point insulin sensitivity estimator (SPISE) index, cognitive performance, and CVS risk in vitamin B₁₂-adequate and -deficient young adults.

Materials and methods: Study participants were 60 young female participants, 18 to 35 years with the inclusion criteria of BMI more than 22.9 and waist circumference >85 cm. Anthropometric variables were measured. Lipid profile analytes were analyzed in an integrated Beckman Coulter AU series autoanalyzer. Based on SPISE index categorized as insulin resistant Group A <5.82 and non-insulin resistant Group B ≥5.82. Cognitive function was assessed based on Mini-Mental State Examination screening tool.

Settings and design: Analytical cross-sectional study.

Results: Individuals with low vitamin B₁₂ levels had a low SPISE index of less than 5.82 and low HDL-C levels, which indicates abnormal lipidemia and reduced insulin sensitivity. Mini-Mental State Examination was low in B₁₂-deficient. B₁₂ revealed positive correlation with MMSE, SPISE Index, and HDLc, whereas negative correlation with TGL and TGL/HDLc ratio.

Conclusion: Individuals with low vitamin B₁₂ levels express low SPISE index, and low performance on MMSE confirms risk of impairment of cognitive function and cardiovascular risk.