休息时的通气长期促进增加了对随后运动通气反应的前馈贡献。

IF 3.3 3区 医学 Q1 PHYSIOLOGY
Journal of applied physiology Pub Date : 2025-02-01 Epub Date: 2025-01-07 DOI:10.1152/japplphysiol.00737.2024
Joseph F Welch, Brighton R Cretney, Gordon S Mitchell, George M Balanos
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引用次数: 0

摘要

呼吸控制系统表现出神经可塑性,可根据经验调整未来的通气反应。我们验证了静息时高碳酸急性间歇缺氧(AIH)诱导的通气长期促进作用可增强随后对稳态运动的通气反应的假设。健康成人14例(年龄= 27±5岁;7名男性)参与了这项研究。第1天进行肺功能检查。在第2天和第3天,以伪随机平衡顺序,参与者暴露于AIH或Sham;AIH包括15,1分钟的缺氧发作和1.5分钟的室内空气间隔。轻度高碳酸血症(潮汐末PCO2比基线高约3mmhg)在AIH和Sham期间持续,并在AIH和Sham后持续40分钟。大约20-30分钟后,参与者在30w, 60w和90w的室内空气中进行连续的轻度至中度恒定负荷循环运动,每次5分钟。AIH后的分钟通气量(⩒I)比基线增加3.6±1.2 L·min-1,显著高于Sham (P = 0.013),表明通气长期促进的开始。虽然AIH和Sham在随后的稳态运动中⩒I没有显著差异(P = 0.511),但⩒I与CO2产速率(即系统增益)和计算的前馈运动增益之间的关系斜率显著增加(P = 0.021和P < 0.001)。因此,AIH后与假手术相比,在所有运动负荷下,潮末二氧化碳分压降低约1 mmHg (P = 0.006)。因此,休息时诱导的通气可塑性改变了未来对轻度或中度稳态运动的通气反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ventilatory long-term facilitation at rest increases the feedforward contribution to subsequent exercise ventilatory responses.

The respiratory control system exhibits neural plasticity, adjusting future ventilatory responses based on experience. We tested the hypothesis that ventilatory long-term facilitation induced by hypercapnic acute intermittent hypoxia (AIH) at rest enhances subsequent ventilatory responses to steady-state exercise. Fourteen healthy adults (age = 27 ± 5 yr; 7 males) participated in the study. On day 1, pulmonary function testing was performed. On days 2 and 3, in a pseudorandomized counterbalanced order, participants were exposed to AIH or Sham; AIH consisted of 15, 1-min hypoxic episodes with 1.5-min room air intervals. Mild hypercapnia (end-tidal Pco2 clamped ∼3 mmHg above baseline) was sustained throughout AIH and Sham and for 40 min after. Approximately 20-30 min later, participants performed continuous mild to moderate constant-load cycle exercise in room air at 30, 60, and 90 W for 5 min each. Inspired minute ventilation (V̇i) increased by 3.6 ± 1.2 L·min-1 after AIH versus baseline and was significantly greater than Sham (P = 0.013), signifying the onset of ventilatory long-term facilitation. Although V̇i during subsequent steady-state exercise was not significantly different between AIH and Sham (P = 0.511), the slope of the relationship between V̇i and CO2 production rate (i.e., the system gain) and the calculated feedforward exercise gain were significantly increased (P = 0.021 and P < 0.001, respectively). Consequently, end-tidal Pco2 was regulated ∼1 mmHg lower across all exercise workloads after AIH versus Sham (P = 0.006). Thus, ventilatory plasticity induced at rest alters future ventilatory responses to mild or moderate steady-state exercise.NEW & NOTEWORTHY We demonstrate that by inducing ventilatory long-term facilitation (LTF) at rest, subsequent ventilatory responses to mild or moderate exercise are altered. When ventilatory LTF was induced via hypercapnic acute intermittent hypoxia, the feedforward contribution to exercise hyperpnea increased, accompanied by marginal increases in the overall system response and decreases in end-tidal Pco2. Thus, respiratory motor plasticity at rest can "spill over" to other physiological states, including mild or moderate steady-state exercise.

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来源期刊
CiteScore
6.00
自引率
9.10%
发文量
296
审稿时长
2-4 weeks
期刊介绍: The Journal of Applied Physiology publishes the highest quality original research and reviews that examine novel adaptive and integrative physiological mechanisms in humans and animals that advance the field. The journal encourages the submission of manuscripts that examine the acute and adaptive responses of various organs, tissues, cells and/or molecular pathways to environmental, physiological and/or pathophysiological stressors. As an applied physiology journal, topics of interest are not limited to a particular organ system. The journal, therefore, considers a wide array of integrative and translational research topics examining the mechanisms involved in disease processes and mitigation strategies, as well as the promotion of health and well-being throughout the lifespan. Priority is given to manuscripts that provide mechanistic insight deemed to exert an impact on the field.
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