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引用次数: 0
摘要
之前的研究对空气污染和乳腺癌风险之间的关系得出了不一致的结论，没有明确的因果关系。为了解决这个问题，我们对来自IEU开放GWAS数据库和乳腺癌协会联盟的数据进行了一项双样本孟德尔随机化研究，以探索空气污染（包括PM2.5、PM2.5吸光度、PM2.5-10、PM10、NO2和NOx）与乳腺癌风险之间的潜在联系。我们发现PM10（比值比(OR) = 1.39, 95% CI: 1.07-1.80, p = 0.013）和NOx （OR = 1.67, 95% CI: 1.16-2.41, p = 0.006）与乳腺癌风险升高显著相关。此外，PM2.5 （OR = 2.10, 95% CI: 1.09-4.03, p = 0.027）和NOx （OR = 3.08, 95% CI: 1.24-7.64, p = 0.015）与腔内B/ her2阴性样癌症的风险升高显著相关。敏感性分析的结果是稳定的。这表明控制空气污染可能会降低患乳腺癌的风险。
Air pollution and breast cancer risk: a Mendelian randomization study.
Previous research yields inconsistent findings on the association between air pollution and breast cancer risk, with no definitive causal relationship established. To address this, we conducted a two-sample Mendelian randomization study on data from the IEU open GWAS databases and the Breast Cancer Association Consortium to explore the potential link between air pollution (including PM2.5, PM2.5 absorbance, PM2.5-10, PM10, NO2, and NOx) and breast cancer risk. We found that PM10 (odds ratio (OR) = 1.39, 95% CI: 1.07-1.80, p = 0.013) and NOx (OR = 1.67, 95% CI: 1.16-2.41, p = 0.006) were significantly associated with elevated breast cancer risk. Furthermore, PM2.5 (OR = 2.10, 95% CI: 1.09-4.03, p = 0.027) and NOx (OR = 3.08, 95% CI: 1.24-7.64, p = 0.015) were significantly associated with an elevated risk of luminal B/HER2-negative-like cancer. Results were stable in sensitivity analyses. This suggested that controlling air pollution could potentially reduce breast cancer risk.
期刊介绍：
International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.
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