成功治疗的年轻牛皮癣患者中残留的非特异性和疾病特异性炎症标志物:一项横断面研究

IF 3.3 4区 医学 Q3 IMMUNOLOGY
Eva Klara Merzel Šabović, Tadeja Kraner Šumenjak, Mojca Božič Mijovski, Miodrag Janić
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引用次数: 0

摘要

牛皮癣是一种慢性免疫介导疾病。银屑病引发的全身炎症显著增加了心血管风险。虽然各种治疗方法都能完全清除皮肤,但对全身炎症的相关影响尚不清楚。我们研究了成功治疗患者的残余全身性炎症。对80例局部治疗、甲氨蝶呤、阿达木单抗、secukinumab或guselkumab成功治疗的银屑病患者(年龄30-45岁)和20例健康对照进行循环疾病特异性和非特异性炎症标志物的测量和比较。测量非特异性炎症标志物(高敏c反应蛋白(hs-CRP)、全血细胞计数(CBC)参数、中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、平均血小板体积与血小板比值(MPR)、红细胞分布宽度与血小板比值(RPR))和疾病特异性炎症标志物(干扰素-γ (IFN-γ)、肿瘤坏死因子(TNF)、白细胞介素(IL)-1β、IL-12p70、IL-17和IL-23)并进行组间比较。与对照组相比,患者的疾病特异性细胞因子(IFN-γ、TNF、IL-1β、IL-12p70和IL-17,但不包括IL-23)显著升高,而非特异性炎症标志物与对照组相比无差异。在所有五个治疗组中,残留的疾病特异性细胞因子同样升高。此外,它们与身体质量指数(BMI)和腰围显著相关。我们的研究结果表明,尽管成功治疗,银屑病患者的残留疾病特异性细胞因子升高,而非特异性炎症标志物与对照组相似。残留的疾病特异性炎症标志物与BMI和腰围相关。体重控制对银屑病患者的有益作用值得进一步研究。该研究于2023年7月24日在http://clinicaltrials.gov(标识符:NCT05957120)注册。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Residual non-specific and disease-specific inflammatory markers in successfully treated young psoriasis patients: a cross-sectional study.

Psoriasis is a chronic, immune-mediated disease. The systemic inflammation triggered by psoriasis contributes significantly to increased cardiovascular risk. While various treatments completely clear the skin, the associated effects on systemic inflammation are not yet clear. We investigated residual systemic inflammation in successfully treated patients. Circulating disease-specific and non-specific inflammatory markers were measured and compared in 80 psoriasis patients (aged 30-45 years) successfully treated with topical therapy, methotrexate, adalimumab, secukinumab or guselkumab, and in 20 healthy controls. Non-specific inflammatory markers (high-sensitivity C-reactive protein (hs-CRP), complete blood count (CBC) parameters, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), mean platelet volume-to-platelet ratio (MPR), and red blood cell distribution width-to-platelet ratio (RPR)) and disease-specific inflammatory markers (interferon-γ (IFN-γ), tumor necrosis factor (TNF), interleukin (IL)-1β, IL-12p70, IL-17, and IL-23) were measured and compared between groups. Disease-specific cytokines (IFN-γ, TNF, IL-1β, IL-12p70, and IL-17, but not IL-23), were significantly elevated in patients compared to controls, while non-specific inflammatory markers showed no differences compared to controls. The residual disease-specific cytokines were similarly elevated in all five treated groups. In addition, they correlated significantly with body mass index (BMI) and waist circumference. Our results suggest that psoriasis patients have elevated residual disease-specific cytokines despite successful treatment, while the non-specific inflammatory markers are similar to those in control subjects. Residual disease-specific inflammatory markers correlated with BMI and waist circumference. A possible beneficial effect of body weight control in psoriasis patients merits further investigation. The study was registered at http://clinicaltrials.gov (identifier: NCT05957120) on July 24, 2023.

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来源期刊
Immunologic Research
Immunologic Research 医学-免疫学
CiteScore
6.90
自引率
0.00%
发文量
83
审稿时长
6-12 weeks
期刊介绍: IMMUNOLOGIC RESEARCH represents a unique medium for the presentation, interpretation, and clarification of complex scientific data. Information is presented in the form of interpretive synthesis reviews, original research articles, symposia, editorials, and theoretical essays. The scope of coverage extends to cellular immunology, immunogenetics, molecular and structural immunology, immunoregulation and autoimmunity, immunopathology, tumor immunology, host defense and microbial immunity, including viral immunology, immunohematology, mucosal immunity, complement, transplantation immunology, clinical immunology, neuroimmunology, immunoendocrinology, immunotoxicology, translational immunology, and history of immunology.
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