乌头根中的二萜类生物碱。

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-01-07 DOI:10.1016/j.fitote.2025.106387

Yan-Yan Luo, Jin-Bu Xu, Shuai Huang, Xian-Li Zhou

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引用次数: 0

摘要

乌头的植物化学研究。首次报道。从球铁根中分离得到2个c20 -二萜生物碱，分别命名为球铁碱A和B(1和2)，3个c19 -二萜生物碱，球铁碱A- c（3-5）和20个已知化合物（6-25）。这些化合物的结构通过综合光谱分析（hresms， IR， 1D和2D NMR）确定。其中球胆碱A(1)是一种具有16,17 -环氧基的松果仁型二萜生物碱。在10 mg/kg的无毒剂量下，14- o -anisoylchasmanine (14) hydrochloride和austroconitine B (17) hydrochloride对醋酸致小鼠扭体的抑制作用分别为83.6% %和83.1% %。

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Diterpenoid alkaloids from the roots of Aconitum bulbilliferum.

The phytochemistry study of Aconitum bulbilliferum Hand.-Mazz. is firstly reported. Two C₂₀-diterpenoid alkaloids, named bulbilliferines A and B (1 and 2), three C₁₉-diterpenoid alkaloids, bulbillifedines A-C (3-5), and twenty known compounds (6-25) were isolated from the roots of A. bulbilliferum. The structures of these compounds were determined by the comprehensive spectroscopic analyses (HRESIMS, IR, 1D and 2D NMR). Among them, bulbilliferine A (1) is a denudatine-type diterpenoid alkaloid bearing a 16, 17-epoxy group. At a nontoxic dose of 10 mg/kg, 14-O-anisoylchasmanine (14) hydrochloride and austroconitine B (17) hydrochloride respectively exhibited the excellent analgesic effects with 83.6 % and 83.1 % inhibitions against acetic acid-induced writhing of mice.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.