可见光诱导丙烯酰胺的自由基级联烷基化/环化：获得3,3-二烷基化氧吲哚。

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-01-02 DOI:10.1039/D4OB01739K

Pengyuan Yang, Lili Wang, Meng Yan, Jinwei Yuan, Yongmei Xiao, Liangru Yang, Xiujuan Xu and Lingbo Qu

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引用次数: 0

摘要

在三环己基膦的存在下，以黄药盐为烷基自由基前体，研究了丙烯酰胺与CS2活化的醇在可见光下的脱氧烷基化/环化反应。它通过串联自由基加成/环化过程进行，该方案提供了一种可靠和实用的方法来建立3,3-二取代吲哚的骨架，收率中等至较高。该反应的显著特点是起始试剂容易获得，底物范围广，反应条件温和。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Visible-light-induced radical-cascade alkylation/cyclization of acrylamides: access to 3,3-dialkylated oxindoles†

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Visible-light-induced radical-cascade alkylation/cyclization of acrylamides: access to 3,3-dialkylated oxindoles†

A visible-light-induced deoxygenative alkylation/cyclization of acrylamides with alcohols activated by CS₂ has been developed by using xanthate salts as alkyl radical precursors in the presence of tricyclohexylphosphine. It proceeds through a tandem radical addition/cyclization process, and this protocol provides a reliable and practical approach to building the skeleton of 3,3-disubstituted oxindoles in moderate to good yields. Notable features of this reaction include readily available starting reagents, broad substrate scope and mild reaction conditions.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.