二硒酸盐作为一种新型有效的荧光猝灭剂，在小鼠中风模型中构建双光子荧光探针检测硫醇。

IF 4.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-01-23 DOI:10.1039/d4cc06286h

Tao Ma, Hao Gao, Jun Wu, Jintao Zhao, Bingbing Chang, Zhibin Zhang, Shengxiang Zhang, Baoxin Zhang, Jianguo Fang

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引用次数: 0

摘要

通过分子内电荷转移（ICT）和Förster共振能量转移（FRET）的结合，首次提出了一种利用线性二烯二化物的荧光猝灭机制。在此，我们合成并筛选了一种双光子荧光探针AFC-SeSe，显示出对谷胱甘肽（GSH）的响应增加了300倍。此外，AFC-SeSe能够在短时间内实时观察脑卒中小鼠模型治疗后硫醇水平的升高。

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Diselenides as novel effective fluorescence quenchers to construct a two-photon fluorescent probe for thiols in a mouse stroke model.

A fluorescence quenching mechanism using linear diselenides was proposed for the first time through a combination of intramolecular charge transfer (ICT) and Förster resonance energy transfer (FRET). Herein, we synthesized and screened a two-photon fluorescent probe AFC-SeSe, demonstrating a remarkable 300-fold increase in response to glutathione (GSH). Additionally, AFC-SeSe enabled real-time observation of increased thiol levels following treatment within a short timeframe in a mouse model of stroke.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.