{"title":"磁性LDH包被DOX和CUR物理上共负载到PEG上，用于靶向和控制药物共同递送到肝癌细胞","authors":"Soheyla Karimi, Hassan Namazi","doi":"10.1007/s10924-024-03430-2","DOIUrl":null,"url":null,"abstract":"<div><p>Nowadays, pH-sensitive and controlled drug delivery systems are urgently required in targeted cancer therapy to increase the drug efficacy and reduce the side effects of cytotoxic drugs. Hence, the present research describes the preparation of Mg-Al-Ca layered double hydroxide (LDH@Fe<sub>3</sub>O<sub>4</sub>) coated with polyethylene glycol (PEG)/doxorubicin (DOX)/curcumin (CUR) for targeted and controlled delivery of DOX and CUR (LDH@Fe<sub>3</sub>O<sub>4</sub>-PEG-DOX-CUR) to liver cancer treatment. The prepared nanocarriers were characterized by FT-IR, FE-SEM, EDX, XRD, BET, VSM, and Zeta potential. The in vitro release investigations of DOX and CUR from the PEG-DOX-CUR and LDH@Fe<sub>3</sub>O<sub>4</sub>-PEG-DOX-CUR confirmed a pH-dependent behavior. The release of drugs from these systems follows the Korsmeyer-Peppas kinetics model. In addition, the LDH@Fe<sub>3</sub>O<sub>4</sub> demonstrated low cytotoxicity and good biocompatibility, as confirmed by in vitro cytotoxicity and DAPI tests against L929 (non-cancerous cells) and HepG2 (human liver cancer cells) cell lines. Whereas, the PEG-DOX-CUR and LDH@Fe<sub>3</sub>O<sub>4</sub>-PEG-DOX-CUR showed higher cytotoxicity effects against HepG2 cells due to targeted co-delivery of DOX and CUR. Based on the findings, the developed nanocarriers have the potential to be utilized as targeted co-drug delivery systems in biomedical applications.</p></div>","PeriodicalId":659,"journal":{"name":"Journal of Polymers and the Environment","volume":"33 1","pages":"269 - 284"},"PeriodicalIF":4.7000,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Magnetic LDH Coated with DOX and CUR Physically Co-loaded onto PEG for Targeted and Controlled Co-delivery of Drugs to Liver Cancer Cells\",\"authors\":\"Soheyla Karimi, Hassan Namazi\",\"doi\":\"10.1007/s10924-024-03430-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Nowadays, pH-sensitive and controlled drug delivery systems are urgently required in targeted cancer therapy to increase the drug efficacy and reduce the side effects of cytotoxic drugs. Hence, the present research describes the preparation of Mg-Al-Ca layered double hydroxide (LDH@Fe<sub>3</sub>O<sub>4</sub>) coated with polyethylene glycol (PEG)/doxorubicin (DOX)/curcumin (CUR) for targeted and controlled delivery of DOX and CUR (LDH@Fe<sub>3</sub>O<sub>4</sub>-PEG-DOX-CUR) to liver cancer treatment. The prepared nanocarriers were characterized by FT-IR, FE-SEM, EDX, XRD, BET, VSM, and Zeta potential. The in vitro release investigations of DOX and CUR from the PEG-DOX-CUR and LDH@Fe<sub>3</sub>O<sub>4</sub>-PEG-DOX-CUR confirmed a pH-dependent behavior. The release of drugs from these systems follows the Korsmeyer-Peppas kinetics model. In addition, the LDH@Fe<sub>3</sub>O<sub>4</sub> demonstrated low cytotoxicity and good biocompatibility, as confirmed by in vitro cytotoxicity and DAPI tests against L929 (non-cancerous cells) and HepG2 (human liver cancer cells) cell lines. Whereas, the PEG-DOX-CUR and LDH@Fe<sub>3</sub>O<sub>4</sub>-PEG-DOX-CUR showed higher cytotoxicity effects against HepG2 cells due to targeted co-delivery of DOX and CUR. Based on the findings, the developed nanocarriers have the potential to be utilized as targeted co-drug delivery systems in biomedical applications.</p></div>\",\"PeriodicalId\":659,\"journal\":{\"name\":\"Journal of Polymers and the Environment\",\"volume\":\"33 1\",\"pages\":\"269 - 284\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2024-10-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Polymers and the Environment\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10924-024-03430-2\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENGINEERING, ENVIRONMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Polymers and the Environment","FirstCategoryId":"5","ListUrlMain":"https://link.springer.com/article/10.1007/s10924-024-03430-2","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, ENVIRONMENTAL","Score":null,"Total":0}
Magnetic LDH Coated with DOX and CUR Physically Co-loaded onto PEG for Targeted and Controlled Co-delivery of Drugs to Liver Cancer Cells
Nowadays, pH-sensitive and controlled drug delivery systems are urgently required in targeted cancer therapy to increase the drug efficacy and reduce the side effects of cytotoxic drugs. Hence, the present research describes the preparation of Mg-Al-Ca layered double hydroxide (LDH@Fe3O4) coated with polyethylene glycol (PEG)/doxorubicin (DOX)/curcumin (CUR) for targeted and controlled delivery of DOX and CUR (LDH@Fe3O4-PEG-DOX-CUR) to liver cancer treatment. The prepared nanocarriers were characterized by FT-IR, FE-SEM, EDX, XRD, BET, VSM, and Zeta potential. The in vitro release investigations of DOX and CUR from the PEG-DOX-CUR and LDH@Fe3O4-PEG-DOX-CUR confirmed a pH-dependent behavior. The release of drugs from these systems follows the Korsmeyer-Peppas kinetics model. In addition, the LDH@Fe3O4 demonstrated low cytotoxicity and good biocompatibility, as confirmed by in vitro cytotoxicity and DAPI tests against L929 (non-cancerous cells) and HepG2 (human liver cancer cells) cell lines. Whereas, the PEG-DOX-CUR and LDH@Fe3O4-PEG-DOX-CUR showed higher cytotoxicity effects against HepG2 cells due to targeted co-delivery of DOX and CUR. Based on the findings, the developed nanocarriers have the potential to be utilized as targeted co-drug delivery systems in biomedical applications.
期刊介绍：
The Journal of Polymers and the Environment fills the need for an international forum in this diverse and rapidly expanding field. The journal serves a crucial role for the publication of information from a wide range of disciplines and is a central outlet for the publication of high-quality peer-reviewed original papers, review articles and short communications. The journal is intentionally interdisciplinary in regard to contributions and covers the following subjects - polymers, environmentally degradable polymers, and degradation pathways: biological, photochemical, oxidative and hydrolytic; new environmental materials: derived by chemical and biosynthetic routes; environmental blends and composites; developments in processing and reactive processing of environmental polymers; characterization of environmental materials: mechanical, physical, thermal, rheological, morphological, and others; recyclable polymers and plastics recycling environmental testing: in-laboratory simulations, outdoor exposures, and standardization of methodologies; environmental fate: end products and intermediates of biodegradation; microbiology and enzymology of polymer biodegradation; solid-waste management and public legislation specific to environmental polymers; and other related topics.
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