关于在药代动力学中使用基尔霍夫定律的关注

IF 3.4 4区医学 Q2 PHARMACOLOGY & PHARMACY

AAPS PharmSciTech Pub Date : 2025-01-09 DOI:10.1208/s12249-024-03019-x

Svein Øie

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引用次数: 0

摘要

在过去的两年中，Kirchhoff电路和电压定律中提出的原理也适用于药代动力学（1-3）。据称，这些原则使肝脏和肾脏中的消除更直接地建模，并为理解为什么有时在生物利用度研究中达到生物利用度值大于100%提供了基本原理。在本文中，它将表明，这些主张是基于错误的翻译基尔霍夫定律的药代动力学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Concerns Regarding the Use of Kirchhoff’s Laws in Pharmacokinetics

Over the last two years the idea that the principles presented in Kirchhoff’s circuit and voltage laws also pertain to pharmacokinetics (1–3). It is claimed that these principles make the elimination in the liver and kidney more straight forward to model and provide a rationale for understanding why sometimes during bioavailability studies one arrives at bioavailability values greater than 100%. In this paper it will be shown that these claims are based on incorrect translations of the Kirchhoff’s Laws to pharmacokinetics.

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来源期刊

AAPS PharmSciTech 医学-药学

CiteScore

6.80

自引率

3.00%

发文量

264

审稿时长

2.4 months

期刊介绍： AAPS PharmSciTech is a peer-reviewed, online-only journal committed to serving those pharmaceutical scientists and engineers interested in the research, development, and evaluation of pharmaceutical dosage forms and delivery systems, including drugs derived from biotechnology and the manufacturing science pertaining to the commercialization of such dosage forms. Because of its electronic nature, AAPS PharmSciTech aspires to utilize evolving electronic technology to enable faster and diverse mechanisms of information delivery to its readership. Submission of uninvited expert reviews and research articles are welcomed.