内前盖：串联控制的动态DNA组装使cGAS-STING刺激的时间选择性正交调节

IF 16.9 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Angewandte Chemie International Edition Pub Date : 2025-01-09 DOI:10.1002/anie.202424929

Xiangfei Li, Dr. Fangzhi Yu, Prof. Lele Li

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引用次数: 0

摘要

李向飞、于方志和李乐乐在e202417916的研究文章中实现了cGAS-STING刺激的时空可控正交调节。在该方法中，酶触发的DNA组装允许cGAS-STING刺激，而光诱导的双链DNA片段可以终止这种刺激，从而实现对免疫调节的正交控制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Inside Cover: Tandem-Controlled Dynamic DNA Assembly Enables Temporally-Selective Orthogonal Regulation of cGAS–STING Stimulation (Angew. Chem. Int. Ed. 7/2025)

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Inside Cover: Tandem-Controlled Dynamic DNA Assembly Enables Temporally-Selective Orthogonal Regulation of cGAS–STING Stimulation (Angew. Chem. Int. Ed. 7/2025)

Spatiotemporally controlled orthogonal regulation of cGAS–STING stimulation has been achieved in the Research Article (e202417916) by Xiangfei Li, Fangzhi Yu and Lele Li. In the approach, enzyme-triggered DNA assembly allows the cGAS–STING stimulation, while light-induced fragmentation of the double-stranded DNA enables termination of such stimulation, thereby achieving orthogonal control over the immune regulation.

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来源期刊

Angewandte Chemie International Edition 化学-化学综合

CiteScore

26.60

自引率

6.60%

发文量

3549

审稿时长

1.5 months

期刊介绍： Angewandte Chemie, a journal of the German Chemical Society (GDCh), maintains a leading position among scholarly journals in general chemistry with an impressive Impact Factor of 16.6 (2022 Journal Citation Reports, Clarivate, 2023). Published weekly in a reader-friendly format, it features new articles almost every day. Established in 1887, Angewandte Chemie is a prominent chemistry journal, offering a dynamic blend of Review-type articles, Highlights, Communications, and Research Articles on a weekly basis, making it unique in the field.