环境苯与中风之间的关系，以及加速生物衰老的中介作用：来自英国生物银行的发现。

IF 7.6 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution Pub Date : 2025-01-08 DOI:10.1016/j.envpol.2025.125656

Guixiang Ji, Yiyi Wang, Zhixi Lu, Guangfeng Long, Cheng Xu

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引用次数: 0

摘要

苯会引起呼吸系统疾病。然而，苯和中风之间的关系尚不清楚。该研究共纳入了来自英国生物银行的13116例中风患者和377120例对照。通过英国环境、食品和农村事务部的数据表，根据每个参与者的地址信息匹配苯暴露浓度。采用加权Cox回归分析苯与卒中风险之间的关系。采用多基因风险评分法（PRS）观察苯暴露与遗传因素对脑卒中风险的共同影响。在本队列研究中，我们进行了中介分析，以探讨加速生物衰老的中介作用。在调整协变量后，苯暴露每增加1 μg/m3，卒中风险增加70%，这可能是由加速的生物老化介导的。高苯暴露浓度和高prs人群中风风险比低苯暴露浓度和低prs人群高44%。苯暴露和PRS对卒中风险有共同影响。苯暴露与中风风险相关，可能是通过增加生物老化，而PRS改变了这种关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Associations between Ambient Benzene and Stroke, and the Mediating Role of Accelerated Biological Aging: Findings from the UK Biobank.

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Associations between Ambient Benzene and Stroke, and the Mediating Role of Accelerated Biological Aging: Findings from the UK Biobank.

Benzene can cause respiratory diseases. However, the associations between benzene and stroke are unclear. A total of 13,116 patients with stroke and 377,120 controls from the UK Biobank were included. The benzene exposure concentrations were matched on the basis of the address information of each participant via a data form from the UK Department for Environment, Food and Rural Affairs. Weighted Cox regression was used to investigate the association between benzene and stroke risk. The polygenic risk score (PRS) was used to observe the joint effects of benzene exposure and genetic factors on stroke risk. We conducted a mediation analysis to investigate the mediating role of accelerated biological aging in this cohort study. After adjusting for covariates, every 1 μg/m³ increase in benzene exposure increased the risk of stroke by 70%, which may be mediated by accelerated biological aging. The population with high benzene exposure concentrations and high PRSs had a 44% greater risk of stroke than did those with low benzene exposure concentrations and low PRSs. Benzene exposure and the PRS have joint effects on the risk of stroke. Benzene exposure was associated with stroke risk, possibly through increased biological aging, and the PRS modified this association.

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来源期刊

Environmental Pollution 环境科学-环境科学

CiteScore

16.00

自引率

6.70%

发文量

2082

审稿时长

2.9 months

期刊介绍： Environmental Pollution is an international peer-reviewed journal that publishes high-quality research papers and review articles covering all aspects of environmental pollution and its impacts on ecosystems and human health. Subject areas include, but are not limited to: • Sources and occurrences of pollutants that are clearly defined and measured in environmental compartments, food and food-related items, and human bodies; • Interlinks between contaminant exposure and biological, ecological, and human health effects, including those of climate change; • Contaminants of emerging concerns (including but not limited to antibiotic resistant microorganisms or genes, microplastics/nanoplastics, electronic wastes, light, and noise) and/or their biological, ecological, or human health effects; • Laboratory and field studies on the remediation/mitigation of environmental pollution via new techniques and with clear links to biological, ecological, or human health effects; • Modeling of pollution processes, patterns, or trends that is of clear environmental and/or human health interest; • New techniques that measure and examine environmental occurrences, transport, behavior, and effects of pollutants within the environment or the laboratory, provided that they can be clearly used to address problems within regional or global environmental compartments.