在一起却有相反的回报

IF 21.2 1区医学 Q1 NEUROSCIENCES

Nature neuroscience Pub Date : 2025-01-08 DOI:10.1038/s41593-024-01861-7

Luis A. Mejia

引用次数: 0

摘要

多巴胺和血清素可能相反地调节联想学习，但它们的确切作用尚未在单个动物中同时得到检验。卡多佐·平托等人在《自然》杂志上发表文章，在巴甫洛夫奖励条件反射任务中，利用双转基因方法从基因上获取小鼠的多巴胺能和血清素能神经元。值得注意的是，在奖励反应中，腹侧纹状体多巴胺轴突活性增加，而血清素轴突活性降低；在多巴胺和血清素指示信号中也观察到类似的模式。多巴胺轴突活性增加或5 -羟色胺轴突活性降低的光致钝化并不会严重损害学习，但反应的双重钝化会损害学习，这表明协调的反向信号对于奖励学习是必要的。条件学习可以通过同时激活和沉默多巴胺和血清素轴突活性来诱导，比单独使用任何一种操作都更强烈。这些结果表明纹状体多巴胺和血清素共同作用，以相反的反应来调节奖励学习。原始参考文献：Nature https://doi.org/10.1038/s41586-024-08412-x （2024）

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Together but opposites in reward

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Nature neuroscience 医学-神经科学

CiteScore

38.60

自引率

1.20%

发文量

212

审稿时长

1 months

期刊介绍： Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.