肿瘤选择性纳米调度器通过调节乳酸代谢和激活toll样受体来增强癌症免疫治疗效果（Small 1/2025）

IF 12.1 2区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Small Pub Date : 2025-01-08 DOI:10.1002/smll.202570005

Yang Liu, Hui Li, Yan-Yun Hao, Ling-Ling Huang, Xia Li, Jing Zou, Shi-Ying Zhang, Xiao-Yue Yang, Hong-Fei Chen, Yi-Xuan Guo, Yun-Yan Guan, Zhi-Yue Zhang

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引用次数: 0

摘要

肿瘤的交付

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Tumor-Selective Nano-Dispatcher Enforced Cancer Immunotherapeutic Effects via Regulating Lactate Metabolism and Activating Toll-Like Receptors (Small 1/2025)

查看原文本刊更多论文

Tumor-Selective Nano-Dispatcher Enforced Cancer Immunotherapeutic Effects via Regulating Lactate Metabolism and Activating Toll-Like Receptors (Small 1/2025)

Tumor-Selective Delivery

In article number 2406870, Zhi-Yue Zhang and co-workers developed a nano-dispatcher to facilitate tumor-selective co-delivery of a monocarboxylate transporter 4 (MCT4) inhibitor and a TLR7/8 agonist. This approach enhances the immunotherapeutic effect by synergistically regulating lactate metabolism and activating dendritic cells.

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来源期刊

Small 工程技术-材料科学：综合

CiteScore

17.70

自引率

3.80%

发文量

1830

审稿时长

2.1 months

期刊介绍： Small serves as an exceptional platform for both experimental and theoretical studies in fundamental and applied interdisciplinary research at the nano- and microscale. The journal offers a compelling mix of peer-reviewed Research Articles, Reviews, Perspectives, and Comments. With a remarkable 2022 Journal Impact Factor of 13.3 (Journal Citation Reports from Clarivate Analytics, 2023), Small remains among the top multidisciplinary journals, covering a wide range of topics at the interface of materials science, chemistry, physics, engineering, medicine, and biology. Small's readership includes biochemists, biologists, biomedical scientists, chemists, engineers, information technologists, materials scientists, physicists, and theoreticians alike.