氟化磷交换（PFEx）点击化学：2‐取代-炔基- 1‐环三磷腈（SACP）枢纽，用于多样性导向点击

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-01-08 DOI:10.1002/adsc.202401573

Zifei Wang, Dharmendra S. Vishwakarma, Shoujun Sun, Qiyao Huang, Soumyaranjan Pati, Robert M. Johnson, Michael R. Rufrano, Milan Gembicky, Joshua Homer, John Edward Moses

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引用次数: 0

摘要

氟化磷交换（PFEx）是一种新的点击化学技术，它依赖于创建创新中心来释放其潜力并扩大其应用范围。在本研究中，我们概述了PFEx集线器开发的一些指导原则，并通过开发一种新的集线器，2 -取代-炔基- 1 -环三磷腈（SACPs）来验证这些原则。这些sacp作为多功能PFEx集线器，具有稳定的功能和正交反应性，例证了它们在多样性定向点击（DOC）框架中的实用性。我们证明了SACPs与各种1,3偶极子相互作用，使富磷化合物能够通过顺序环加成和PFEx反应合成，从而开辟了新的合成路线，广泛应用于点击化学。

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Phosphorus Fluoride Exchange (PFEx) Click Chemistry: 2‐Substituted‐alkynyl‐1‐cyclotriphosphazene (SACP) Hubs for Diversity Oriented Clicking

Phosphorus Fluoride Exchange (PFEx) is a new click chemistry technology that hinges on the creation of innovative hubs to unlock its potential and broaden its applications. In this study, we outline some guiding principles for PFEx hub development and validate these principles by developing a new hub, 2‐substituted‐alkynyl‐1‐cyclotriphosphazenes (SACPs). These SACPs serve as versatile PFEx hubs with stable functionality and orthogonal reactivity, exemplifying their utility within the Diversity Oriented Clicking (DOC) framework. We demonstrate that SACPs interact with various 1,3‐dipoles, enabling the synthesis of phosphorus‐rich compounds through sequential cycloaddition and PFEx reactions, thus pioneering new synthetic routes for wide application of click chemistry.

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.