氨基乙酰丙酸光动力治疗术后白色念珠菌所致复发性皮肤肉芽肿1例报告。

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2025-02-01 DOI:10.1016/j.pdpdt.2024.104466

Lulu Wang , Yahui Feng , Sisi Wang , Leyao Shi , Yong Ren , Zhiya Yang , Dongmei Shi

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引用次数: 0

摘要

光动力疗法（PDT）是一种将光敏药物与光结合，主要通过氧化损伤诱导靶细胞产生光毒性反应的治疗方法。PDT联合抗真菌药物成功治疗念珠菌感染的病例报道较少。我们提出了一例皮肤肿块引起的白色念珠菌（白色念珠菌）单独治疗5-氨基乙酰丙酸(ALA)- PDT。一名21岁女性右肘皮肤病变。以手术切除后持续3个月的红斑、结节和囊肿为特征。通过对分离病原菌的组织病理学、形态学和分子序列分析，确定白色念珠菌引起的感染性肉芽肿的诊断。间隔9天进行两次ALA-PDT治疗后，病变完全消失。随访6个月，无复发迹象。本病例提示，对于白色念珠菌深部感染引起的体表单一病变，单ala - pdt是一种有效的治疗选择。

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Successful management of recurrent cutaneous granulomas caused by Candida albicans using aminolevulinic acid photodynamic therapy post-surgery: A case report

Photodynamic therapy (PDT) is a treatment that combines a photosensitive drug with light to induce phototoxic response in target cells, primarily through singlet oxygen.. Few cases have reported the combination of PDT with antifungal agents to successfully treat Candida infection. We present a case of cutaneous mass caused by Candida albicans (C.albicans) treated solely with 5-aminolevulinic acid (ALA)- PDT. A 21-year-old female presented with a cutaneous lesion on her right elbow,. characterized by erythema, nodules, and cysts that had persisted for 3 months after surgical excision. The diagnosis of infectious granulomas caused by C. albicans was confirmed through tissue histopathological, morphology and molecular sequence of the isolated pathogen. The lesion was completely resolved after two sessions of ALA-PDT adminstered 9 days apart. During the 6-month follow-up, there were no signs of relapse. This case suggested that mono-ALA-PDT can be an effective treatment option for single lesion on the body surface caused by C. albicans deep infection.

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.